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甲胎蛋白、α-L-岩藻糖苷酶、癌胚抗原和 糖类抗原19-9联合检测对肝癌诊断的价值 被引量:1

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摘要 目的:分析甲胎蛋白(AFP)、a-L-岩藻糖苷酶(AFU)、癌胚抗原(CEA)及糖类抗原19-9(CA19-9)联合检测对肝癌的诊断价值。方法:选取86例肝部疾病患者作为研究对象。以手术病理组织检查或影像学、免疫学诊断结果为金标准,比较肝癌患者和良性肝病患者AFP、AFU、CEA和CA19-9水平,并绘制受试者工作曲线(ROC),分析AFP、AFU、CEA和CA19-9水平单一和联合检测诊断肝癌的价值。结果:诊断结果显示,86例患者中,原发性肝癌42例;良性肝病44例,其中肝硬化20例,肝炎24例。肝癌患者AFP、AFU、CEA和CA19-9水平均明显高于良性肝病患者,差异有统计学意义(P<0.05)。将肝癌作为状态变量(1=肝癌,0=良性肝病),将AFP、AFU、CEA和CA19-9单一检测及联合检测作为检验变量,绘制ROC曲线,得到联合检测诊断肝癌的敏感度和特异度均高于单一检测诊断。结论:AFP、AFU、CEA和CA19-9水平联合检测诊断肝癌的敏感度和特异度均高于单一检测诊断。
作者 孙金旗
出处 《中国民康医学》 2020年第18期103-105,共3页 Medical Journal of Chinese People’s Health
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