摘要
目的检测血清中甲状腺激素水平在慢性乙型肝炎、乙肝肝硬化患者中的变化,探究其临床价值。方法选取医院2016年1月—2019年12月收治的健康体检者48例、慢性乙型肝炎60例(轻、中、重患者各20例)、乙肝肝硬化患者60例(Child-Pugh A、B、C三组各20例),检测其血清促甲状腺激素(TSH)、四碘甲腺原氨酸(T4)、三碘甲腺原氨酸(T3)、游离四碘甲腺原氨酸(FT4)、游离三碘甲腺原氨酸(FT3),将结果进行比对;并将慢性乙型肝炎轻中重度患者及肝硬化患者中不同Child分级,进行对比及统计分析。结果慢性肝炎、肝硬化组患者TSH水平高于健康体检者,血清甲状腺素T3、FT3和T4、FT4的水平随肝功能损伤程度增加而降低,差异有统计学意义(P<0.05)。肝硬化组患者TSH水平随着肝功能级别升高而升高,但组间差异不具有统计学意义(P>0.05),血清T3、T4、FT3、FT4水平随着肝功能级别升高而降低,组间差异均有统计学意义(均P<0.05)。结论随着肝功能损伤程度增加,血清甲状腺激素T3、FT3和T4、FT4的水平逐渐降低。血清TSH会因肝功能损伤受影响,但无统计学意义。
Objective To explore the clinical value of serum Thyroid hormone in patients with chronic hepatitis B and hepatitis B Cirrhosis.Methods From January 2016 to December 2019,48 cases of Health check-up,60 cases of chronic hepatitis B(20 cases each),60 cases of hepatitis B CIRRHOSIS(20 cases each in Child-PughA,B and C groups)were treated,Serum thyroid stimulating hormone(TSH),tetraiodothyronine(T4),triiodothyronine(T3),free tetraiodothyronine(FT4)and free triiodothyronine(FT3)were detected and compared.The Child grades of patients with chronic hepatitis B and cirrhosis were compared and analyzed statistically.Results The level of TSH in patients with chronic hepatitis and cirrhosis was higher than that in healthy subjects.The levels of T3,FT3,T4 and FT4 in serum decreased with the degree of liver function injury.The difference was statistically significant(P<0.05).The level of TSH in liver cirrhosis group increased with the increase of liver function,but there was no significant difference between the two groups(P>0.05),The levels of serum T3,T4,FT3 and FT4 decreased with the increase of liver function,and the differences were statistically significant(all P<0.05).Conclusion The levels of T3,FT3,T4 and FT4 in serum decreased gradually with the increase of liver function injury.Serum TSH was affected by liver function injury,but there was no statistics significance.
作者
钱贤峰
刘娜娜
QIAN Xianfeng;LIU Na’na(Department of Gastroenterology,The Third People’s Hospital of Changzhou,Changzhou Jiangsu 213000,China)
出处
《中国继续医学教育》
2020年第31期107-110,共4页
China Continuing Medical Education
