摘要
目的分析通窍活血汤联合阿托伐他汀治疗对缺血性脑卒中脑动脉狭窄患者临床疗效的影响。方法112例缺血性脑卒中脑动脉狭窄患者,按照治疗方式分为联合组和对照组各56例。对照组口服阿托伐他汀钙片及阿司匹林肠溶片,联合组在对照组基础上增服通窍活血汤。比较两组临床疗效、治疗前后血脂[甘油三酯(TG)、胆固醇(CHOL)及低密度脂蛋白胆固醇(LDL-C)]及炎性因子[C反应蛋白(CRP)、白细胞介素6(IL-6)及肿瘤坏死因子α(TNF-α)]水平、治疗期间不良反应发生情况。结果联合组临床总有效率高于对照组(P<0.05);治疗后两组CRP、IL-6、TNF-α、TG、CHOL及LDL-C水平均下降,联合组均低于对照组(P<0.05);两组治疗期间不良反应发生率比较差异无统计学意义(P>0.05)。结论通窍活血汤联合阿托伐他汀治疗可降低缺血性脑卒中脑动脉狭窄患者血脂水平,减轻炎症反应,临床疗效佳且安全性高。
Objective To analyze the effects of Tong-qiao-huo-xue decoction combined with atorvastatin on the clinical efficacy of patients with cerebral artery stenosis of ischemic stroke.Methods One hundred and twelve patients with cerebral artery stenosis of ischemic stroke admitted in our hospital were selected and divided into a combination group and a control group according to the treatment methods,56 in each group.The control group was treated with orally administration of atorvastatin calcium tablets and aspirin enteric-coated tablets,and the combination group was supplemented with Tong-qiao-huo-xue decoction based on the treatment of the control group.Clinical efficacy and blood lipid levels such as triglyceride (TG),cholesterol (CHOL) and low-density lipoprotein cholesterol (LDL-C) and inflammatory factors such as C-reactive protein (CRP),interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) before and after treatment were compared between the two groups.The incidence of adverse reactions including gastrointestinal bleeding,intracranial bleeding,gastrointestinal reactions,and rash was compared between the two groups.Results The total clinical effective rate of the combined group was higher than that of the control group ( P <0.05).After treatment,the levels of CRP,IL-6,TNF-α,TG,CHOL,and LDL-C in both groups were decreased,and levels of CRP,IL-6,TNF-α,TG,CHOL and LDL-C in the combination group were lower than those in the control group ( P <0.05).There were no significant differences in incidence of adverse reactions between the two groups during treatment ( P >0.05).Conclusion Tong-qiao-huo-xue decoction combined with atorvastatin can reduce blood lipid levels and reduce inflammation in patients with cerebral artery stenosis of ischemic stroke.It has good clinical efficacy and high safety.
作者
东潇博
宋崇文
王革生
张凡帆
宋光荣
蔡旭
王雷
DONG Xiao-bo;SONG Chong-wen;WANG Ge-sheng;ZHANG Fan-fan;SONG Guang-rong;CAI Xu;WANG Lei(Dongfang Hospital Beijing University of Chinese Medicine,Beijing 100078,China;Nanyuan Hospital,Fengtai District,Beijing 100078,China)
出处
《实用医院临床杂志》
2020年第6期3-6,共4页
Practical Journal of Clinical Medicine
基金
北京市自然科学基金资助项目(编号:7172250)。
关键词
通窍活血汤
阿托伐他汀
缺血性脑卒中
血脂
Tong-qiao-huo-xue decoction
Atorvastatin
Ischemic stroke
Blood lipid
