摘要
目的探究链霉蛋白酶颗粒在幽门螺杆菌(Hp)根除治疗中的应用价值。方法随机选取2019年1月~2020年1月接受Hp根除治疗的患者共120例,采用随机数表法分为观察组和对照组各60例。对照组患者采用雷贝拉唑钠、克拉霉素与阿莫西林三联疗法治疗14 d,观察组患者在此基础上予以链霉蛋白酶颗粒口服。治疗结束4周及6个月后评估临床疗效及Hp根除情况。结果治疗后4周复查显示观察组患者治疗总有效率(96.67%)与Hp根除率(91.67%)明显高于对照组患者(86.67%和76.67%),且6个月后观察组患者Hp复发率(12.73%)显著低于对照组患者(32.61%)(P<0.05)。结论在Hp根除治疗中三联疗法联合链霉蛋白酶颗粒可有效提高治疗效果。
Objective To explore the application value of pronase granules in the eradication treatment of helicobacter pylori(Hp).Methods A total of 120 patients who received Hp eradication in hospital from January 2019 to January 2020 were randomly selected.Patients in the control group were treated with omeprazole,clarithromycin and amoxicillin for 14 days,and patients in the observation group were given pronase granules orally.Efficacy and Hp eradication were assessed 4 weeks and 6 months after treatment.Results 4 weeks after treatment,the total effective rate(96.67%)and Hp eradication rate(91.67%)in the observation group were significantly higher than that in the control group(86.67%and 76.67%),and the Hp recurrence rate(12.73%)in the observation group was significantly lower than that in the control group(32.61%)(P<0.05).Conclusion Triple therapy combined with pronase granules can effectively improve the curative effect in the eradication of Hp.
作者
曹靓
王浩浩
孟祥云
CAO Liang;WANG Hao-hao;MENG Xiang-yun(Department of pharmacy,The Second People's Hospital of Hefei,Hefei 230011,China)
出处
《中国处方药》
2020年第11期85-86,共2页
Journal of China Prescription Drug
关键词
链霉蛋白酶
幽门螺杆菌
根除治疗
Pronase granules
Helicobacter pylori
Eradication therapy
