摘要
1型糖尿病(T1DM)是一种胰岛β细胞被破坏,导致胰岛素分泌绝对不足的自身免疫性疾病,占糖尿病的10%~15%,其中青少年发病较多,且呈逐年上升趋势。对于T1DM的治疗多以终生外源性胰岛素补充为主,严重影响生活质量,同时很容易发生多种合并症。在T1DM的发病过程中,胰岛β细胞发生损伤与死亡,胰岛β细胞的死亡方式主要有细胞凋亡、细胞焦亡、自噬和坏死等4种。文章就胰岛β细胞的不同死亡方式进行综述,以期对T1DM的治疗和预后提供新的等思路。
Type 1 diabetes(T1DM)is an autoimmune disease in which pancreaticβ-cells are destroyed,resulting in absolute insufficient insulin secretion.It accounts for 10%to 15%of diabetes.Among them,adolescents have more incidences and are increasing year by year.The treatment of T1DM is mostly based on life-long exogenous insulin supplementation,which seriously affects the quality of life,and it is prone to multiple complications.In the pathogenesis of T1DM,pancreaticβ-cells are damaged and die.The main death modes of pancreaticβ-cells are apoptosis,pyrolysis,autophagy and necrotic cell death.This article reviews the different death modes of pancreaticβ-cells in order to provide new ideas for the treatment and prognosis of T1DM.
作者
张晓宇(综述)
冷锦红(审校)
Zhang Xiaoyu;Leng Jinhong(Liaoning University of Traditional Chinese Medicine,Liaoning Province,Shenyang 110032,China;不详)
出处
《疑难病杂志》
CAS
2020年第11期1170-1173,共4页
Chinese Journal of Difficult and Complicated Cases
基金
辽宁省自然科学基金计划重点项目(20180530030)
辽宁“百千万人才工程”培养经费资助项目(辽人社[2018]47号)
沈阳市科技计划项目(18-013-0-09)。
