摘要
目的对复方青黛胶囊治疗玫瑰糠疹的临床疗效及安全性进行评价,旨在评估复方青黛胶囊治疗的可行性及治疗方案的优势。方法电子检索PubMed、EMbase、Cochrane Library、知网(CNKI)、万方(WangFang)、维普(VIP)、中国生物医学文献数据库(CBM),手工检索相关皮肤专科杂志,全面收集复方青黛胶囊治疗玫瑰糠疹的随机对照试验。检索时间为2000年1月至2020年9月,由2名研究者根据纳排标准独立筛选文献,评估偏倚风险并交叉核对,提取数据,采用RevMan5.3.5进行Meta分析。结果共纳入10篇文献,824名受试者。比较了复方青黛胶囊单用或联合应用与对照组治疗玫瑰糠疹的疗效差异。Meta分析结果显示,在玫瑰糠疹治愈率[OR=3.16,95%CI(2.33,4.27)]、有效率[OR=0.45,95%CI(0.30,0.66)]、症状体征评分:红斑[MD=-2.73,95%CI(-5.17,-0.29)]、瘙痒[MD=-2.01,95%CI(-3.76,-0.26)]方面均明显优于对照组;在显效率[OR=0.93,95%CI(0.67,1.28)]、症状体征评分:鳞屑[MD=-2.75,95%CI(-7.59,2.09)]方面与对照组相当,无统计学意义。复方青黛胶囊不良反应主要为轻微的胃肠不适症状,嗜睡、皮肤红斑、灼热等症状主要为抗组胺药和UVB照射所致。结论复方青黛胶囊单用或联合应用可明显提高临床治愈率、有效率,改善皮肤红斑、瘙痒症状,安全性较好。
Objective To evaluate the clinical efficacy and safety of compound Qingdai capsules in the treatment of pityriasis rosea,in order to evaluate the feasibility of compound Qingdai capsules and the advantages of the treatment scheme.Methods Electronic retrieval of PubMed,EMbase,Cochrane Library,CNKI,WangFang,VIP and China Biomedical Literature Database(CBM),manual retrieval of related dermatology journals,and comprehensive collection of randomized controlled trials of compound Qingdai capsules in treating pityriasis rosea.The retrieval time was from January 2000 to September 2020,and two researchers independently screened the literatures according to the criteria of inclusion,evaluated the risk of bias and cross-checked,extracted the Meta,and conducted meta-analysis with RevMan5.3.5.Results A total of 8 articles and 676 subjects were included.The efficacy of compound Qingdai capsules alone or in combination with the control group was compared in the treatment of pityriasis rosea.Meta-analysis showed that the cure rate of pityriasis rosea[OR=3.16,95%CI(2.33,4.27)],effective rate[OR=0.45,95%CI(0.30,0.66)],symptom and sign score:erythema[MD=-2.73,95%CI(-5.17,-0.29)],itching[MD=-2.01,95%CI(-3.76,-0.26)]are significantly better than the control group;in the significant efficiency[OR=0.93,95%CI(0.67,1.28)],symptom and sign score:scale[MD=-2.75,95%CI(-7.59,2.09)]is comparable to the control group and has no statistical significance.The adverse reaction of compound Qingdai capsules is mainly mild gastrointestinal discomfort symptoms,and symptoms such as drowsiness,skin erythema,and burning are mainly caused by antihistamines and UVB radiation.Conclusion compound Qingdai capsules used alone or in combination can significantly increase the clinical cure rate and effective rate,improve skin erythema and itching symptoms,and have good safety.
作者
杨雪圆
蔡宛灵
闫小宁
YANG Xue-yuan;CAI Wan-ling;YAN Xiao-ning(Hospital Dermatological Department of Shaanxi Province,Shaanxi Province,710003,China)
出处
《中国医疗美容》
2020年第10期66-73,共8页
China Medical Cosmetology
基金
国家重点研发计划“中医药现代化研究重点专项”(No.2018YFC1705303)。
关键词
复方青黛胶囊
玫瑰糠疹
疗效
随机对照试验
META分析
Compound Qingdai capsules
Pityriasis rosea
Efficacy
Randomized controlled trial
Meta analysis
