摘要
目的阐述患者因服用非甾体抗炎药致上消化道出血的相关临床特征,为合理用药提供借鉴。方法2019年1月—2020年1月抽选该院收治的上消化出血患者118例,根据患者是否服用非甾体抗炎药物情况分为两组,对照组患者均为未服用非甾体抗炎药物的患者,观察组上消化道出血患者则服用过非甾体抗炎药物,分别对比两组患者基础信息差异,包括性别、年龄、消化道病史、幽门螺杆菌感染情况、出血量、症状表现等,分析因非甾体抗炎药引起上消化道出血的患者特征,同时列举几类常用非甾体抗炎药物。结果两组上消化道出血患者性别、消化道病史、幽门螺杆菌感染情况大致相近(P>0.05),而观察组患者年龄超过60岁占比71.19%,较对照组50.85%更高,出血量超过1000 mL、无症状表现患者例数占比67.80%、59.32%,相较对照组27.12%、10.17%更多(χ2=18.010、15.820,P<0.05)。较为常用的非甾体抗炎药物包括美洛昔康、尼美舒利、双氯芬酸钠、布洛芬。结论因服用非甾体抗炎药物致上消化道出血患者临床特征通常为年龄偏高、出血量多、症状表现不明显等,因此,在诊治上消化道出血患者时,应结合患者基本信息,分析有无服用药物情况,以便对症治疗,促进患者康复。
Objective To describe the clinical characteristics of upper gastrointestinal bleeding caused by non-steroidal anti-inflammatory drugs in patients,and to provide references for rational drug use.Methods From January 2019 to January 2020,118 patients with digestive bleeding in the hospital were selected and divided them into two groups according to whether the patients were taking non-steroidal anti-inflammatory drugs.Patients in the control group were all patients who did not take non-steroidal anti-inflammatory drugs,and patients in the observation group with upper gastrointestinal bleeding had taken non-steroidal anti-inflammatory drugs.The differences in basic information between the two groups were compared,including gender,age,and digestive tract history,Helicobacter pylori infection,bleeding volume,symptoms,etc,analyze the characteristics of patients with upper gastrointestinal bleeding caused by non-steroidal anti-inflammatory drugs,and list several types of commonly used non-steroidal anti-inflammatory drugs.Results The two groups of patients with upper gastrointestinal bleeding were roughly similar in gender,gastrointestinal history,and Helicobacter pylori infection(P>0.05),and the observation group was more than 60 years old accounting for 71.19%of patients than the control group 50.85%;the number of patients with bleeding volume exceeding 1000 mL and asymptomatic manifestations accounted for 67.80%and 59.32%,compared with 27.12%and 10.17%in the control group,the observation group accounted for a higher proportion(χ2=18.010,15.820,P<0.05).The more commonly used non-steroidal anti-inflammatory drugs include meloxicam,nimesulide,diclofenac sodium,and ibuprofen.Conclusion The clinical characteristics of patients with upper gastrointestinal bleeding caused by taking non-steroidal anti-inflammatory drugs are usually high age,heavy bleeding,and unobvious symptoms.Therefore,when diagnosing and treating patients with upper gastrointestinal bleeding, the basic information of the patient should be combined. Analyze the presence or absence of medications for symptomatic treatment and promote patient recovery.
作者
王美芳
吴元祥
WANG Mei-fang;WU Yuan-xiang(Department of Pharmacy,Rugao Hospital of Traditional Chinese Medicine,Rugao,Jiangsu Province,226500 China;Department of Gastroenterology,Rugao Hospital of Traditional Chinese Medicine,Rugao,Jiangsu Province,226500 China)
出处
《世界复合医学》
2020年第10期138-140,共3页
World Journal of Complex Medicine
关键词
非甾体抗炎药
上消化道出血
临床特征
Non-steroidal anti-inflammatory drugs
Upper gastrointestinal bleeding
Clinical features
