摘要
目的探讨成人慢性活动性EB病毒感染(CAEBV)患者的临床特征及外周血淋巴细胞免疫表型。方法回顾性纳入2017年3月至2019年3月如皋市人民医院收治的48例成人CAEBV感染者,记录患者一般临床资料及EB病毒相关抗体、病毒载量和细胞免疫表型。结果48例成人CAEBV患者年龄(40.8±14.4)岁,均有发热症状。严重肝功能衰竭、Hermansky-Pudlak综合征(HPS)、中枢神经系统(CNS)病变和间质性肺炎发生率分别为29.2%(14/48)、47.9%(23/48)、12.5%(6/48)和22.9%(11/48)。患者血浆EBV DNA拷贝数中位数为2.9×10^4(5×10^2~5.8×10^6)拷贝/ml。32例患者完成外周血淋巴细胞免疫表型检测,B细胞、NK细胞、CD4^+T细胞、CD8^+T细胞水平分别为25×10^9/L(0,19.6×10^9/L)、82.5×10^9/L(54×10^9/L,183×10^9/L),332.5×10^9/L(178.25×10^9/L,534.25×10^9/L),302×10^9/L(190×10^9/L,573.5×10^9/L),53.1%(25/48)患者出现CD4/CD8比值倒置(<1)。CD38+CD8+T细胞百分比中位数为93.2%(49.1%,99.7%),HLA-DR+CD8^+T细胞百分比的中位数为71.25%(17.1%,97.5%)。结论成人CAEBV患者的临床特征与其外周血淋巴细胞免疫表型关系密切,B细胞、NK细胞和CD4^+T细胞水平多降低。
Objective To investigate the clinical characteristics and peripheral blood lymphocytes immunophenotype of adult patients with chronic active Epstein-Barr virus(CAEBV).Methods A retrospective study included 48 adult patients with CAEBV in Rugao People’s Hospital from March 2017 to March 2019.The general clinical information and EBV virus-related antibody,viral load and cellular immunophenotypic correlation tests were recorded.Results The median age of 48 adult patients with CAEBV was(40.8±14.4)years old.All patients had fever symptoms.The incidence of severe liver failure,Hermansky-Pudlak syndrome(HPS),central nervous system(CNS)lesions and interstitial pneumonia were 29.2%(14/48),47.9%(23/48),12.5%(6/48)and 22.9%(11/48),respectively.The median copies of EBV DNA of CAEBV patients was 2.9×10^4 copies/ml(5×10^2-5.8×10^6 copies/ml).A total of 32 patients completed peripheral blood lymphocyte immunophenotyping,with the median of B cells,natural killer(NK)cell,CD4^+T cells and CD8^+T cells were 25×10^9/L(0,19.6×10^9/L),82.5×10^9/L(54×10^9/L,183×10^9/L),332.5×10^9/L(178.25×10^9/L,534.25×10^9/L)and 302×10^9/L(190×10^9/L,573.5×10^9/L).There were 53.1%(25/48)of patients had a CD4/CD8 ratio inversion(<1).The median percentage of CD38^+CD8^+T cells was 93.2%(49.1%,99.7%),and the median percentage of HLA-DR^+CD8^+T cells was 71.25%(17.1%,97.5%).Conclusions The clinical characteristics of adult patients with CAEBV were closely related to peripheral blood lymphocytes immunophenotype,and the levels of B cells,NK cells and CD4^+T cells decreased.
作者
凌炜焱
丁俊琪
田芝奥
姚建华
Ling Weiyan;Ding Junqi;Tian Zhiao;Yao Jianhua(Department of Infectious Diseases,Rugao People’s Hospital,Rugao 226500,China)
出处
《中华实验和临床感染病杂志（电子版）》
CAS
2020年第5期424-428,共5页
Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)
关键词
EB病毒
免疫表型
成人
Epstein-Barr virus
Immunophenotype
Adult onset
