摘要
光热治疗是一种非侵入式、靶向性的新型治疗技术,但现有的光热治疗技术不能实时监测靶区的温度分布,且开环的激光控制方式不仅增大了治疗难度,也会对病灶周边的正常组织造成不可逆损伤。为此,提出了一种基于光声温度精准调控的光热治疗方法。研究了基于光声图像的温度成像算法,提出了光声温度敏感因子的概念,设计了基于光声温度敏感因子的闭环温度控制算法,最后搭建了一套基于光声温度精准调控的新型光热治疗系统,并进行了仿体实验。实验结果表明:基于光声温度精准调控的光热治疗方法可实现靶区温度的非接触式精准测量与控制,系统调节时间在10 s以内且温度控制均方根误差在0.7 ℃以内。基于光声温度精准调控的光热治疗方法可以作为一种更精准、高效的辅助手段应用于光热治疗领域。
Photothermal therapy is a non-invasive, targeted, and new technology, but the existing photothermal therapy technology cannot monitor the temperature distribution of the target area in real time, and the open-loop laser control method not only increases the difficulty of treatment but also causes irreversible damage to normal tissues around patient''s lesion. This paper proposes a photothermal therapy method based on precise control of photoacoustic temperature. The proposed temperature imaging algorithm was studied, the concept of photoacoustic temperature sensitivity factor was proposed and a closed-loop temperature control algorithm was designed based on the factor. Finally, a new photothermal treatment system was designed based on precise control of photoacoustic temperature, and phantom experiments were conducted. The experimental results show that the photothermal therapy method based on the precise control of photoacoustic temperature can realize the non-contact accurate measurement and control function of the target zone temperature. The system adjustment time is within 10 s and the temperature control steady-state error is within 0.7 ℃. Additionally, the results show that the photothermal therapy method based on the precise control of photoacoustic temperature can be used as a more accurate and efficient auxiliary method in the field of photothermal therapy.
作者
马一鸣
马立勇
秦泽政
孙明健
Ma Yiming;Ma Liyong;Qin Zezheng;Sun Mingjian(School of Information Science and Engineering,Harbin Institute of Technology,Weihai,Shandong 264209,China;School of Astronautics,Harbin Institute of Technology,Harbin,Heilongjiang 15000,China)
出处
《中国激光》
EI
CAS
CSCD
北大核心
2020年第10期203-213,共11页
Chinese Journal of Lasers
基金
国家重点研发计划(2017YFE0121000,2018YFC0114800)
国家自然科学基金(11574064,11874133)
山东省自然科学基金(ZR2017MF041,ZR2018MF026)
山东省重点研发计划(2018GGX103047,2016GGX103032)。
关键词
医用光学
光热治疗
光声测温
敏感因子
精准调控
medical optics
photothermal therapy
photoacoustic temperature measurement
sensitive factors
precise regulation
