摘要
目的研究小儿惊风七厘散联合喜炎平治疗小儿轮状病毒肠炎合并神经损伤患儿的疗效及对血清神经营养因子(NTF)及神经生长因子(NGF)、脑源性神经营养因子(BDNF)、神经元特异性烯醇化酶(NSE)及髓磷脂碱性蛋白(MBP)含量的影响。方法选取2013年1月—2016年1月接受治疗的94例轮状病毒肠炎并发神经损伤患儿作为研究对象,利用随机数字表法将其分为观察组和对照组。对照组患儿给予喜炎平注射液治疗,观察组在对照组治疗基础上同时给予小儿惊风七厘散。两组患儿的治疗时间均为10 d。治疗后,评价两组治疗效果;观察两组患儿神经系统症状、腹痛、腹鸣、恶心呕吐及腹泻的缓解时间;治疗前后,检测两组患儿血清NTF、NGF、BDNF、NSE及MBP含量,血清超敏C反应蛋白(hs-CRP)、白细胞介素-4(IL-4)、白细胞介素-8(IL-8)及肿瘤坏死因子-α(TNF-α)含量;观察患儿治疗中出现的不良反应。结果观察组治疗后总有效率明显高于对照组(P<0.05);观察组神经系统症状、腹痛、腹鸣、恶心呕吐及腹泻缓解时间均明显短于对照组(P<0.05);治疗后,观察组NTF、NGF及BDNF含量均明显高于对照组(P<0.05),NSE、MBP、hs-CRP、IL-4、IL-8及TNF-α含量均明显低于对照组(P<0.05)。结论小儿惊风七厘散联合喜炎平治疗小儿轮状病毒肠炎合并神经损伤患儿疗效较好,且能够有效改善患儿血清NTF、NGF、BDNF、NSE及MBP水平。
Objective To study the effects of Xiaoer Jingfeng Qili San combined with Xiyanping Injection in treating infantile rotavirus enteritis and its influence on the levels of NTF,NGF,BDNF,NSE and MBP in the patients.Method Ninety-four children with rotavirus enteritis and nerve injury who received treatment from January 2013 to January 2016 were selected as the research objects,and they were divided into observation group and control group by random number table method.The control group was treated with Xiyanping injection and observation group given Xiaoer Jingfeng Qili San on the base of control group.After the treatment,the effects were compared in the 2 groups.The release time of nervous system symptoms,abdominal pain,borborygmus,nausea and vomiting,diarrhea were compared in the 2 groups.Before and after the treatment,the levels of NTF,NGF,BDNF,NSE,MBP,hs-CRP,IL-4,IL-8 and TNF-α were detected in the 2 groups.The adverse actions in the two patients were observed.Result The total effective rate after treatment in the observation group was significantly higher than that in the control group(P<0.05);the relief time of neurological symptoms,abdominal pain,abdominal pain,nausea,vomiting and diarrhea in the observation group was significantly shorter than that in the control group(P<0.05).After treatment,the contents of NTF,NGF and BDNF in the observation group were significantly higher than those in the control group(P<0.05),and the contents of NSE,MBP,hs-CRP,IL-4,IL-8 and TNF-αwere significantly lower than those in the control group(P<0.05).Conclusion Xiaoer Jingfeng Qili San combined with xiyanping injection in treating infantile rotavirus enteritis has a good effect and could significantly promote the levels of NTF,NGF,BDNF,NSE and MBP in the patients.
作者
白进
王英娟
亢相逢
雷伟
师改芳
丁貂
刘艳
贺译平
BAI Jin;WANG Ying-juan;KANG Xiang-feng;LEI Wei;SHI Gai-fang;DING Diao;LIU Yan;HE Yi-ping(Department of Pediatrics,Yulin First Hospital,Yulin Shaanxi 719000;Department of Pediatrics,Northwest Women and Children′s Hospital,Xi′an Shaanxi 710061)
出处
《世界中西医结合杂志》
2020年第10期1841-1845,共5页
World Journal of Integrated Traditional and Western Medicine
基金
陕西省社会发展科技攻关项目(2015SF135)。
关键词
轮状病毒肠炎
小儿惊风七厘散
喜炎平
神经损伤
Rotavirus Enteritis
Xiaoer Jingfeng Qili San
Xiyanping Injection
Nervous Injury
