摘要
目的探讨八珍颗粒治疗抗结核药相关性白细胞减少的临床疗效及安全性。方法选择肺结核患者288例,根据随机数字表法分为试验组与对照组,每组各144例。两组患者均给予正规抗结核治疗。此外,试验组患者予以八珍颗粒口服,1包/次,2次/d;对照组患者予以安慰剂口服,1包/次,2次/d。治疗4周后比较两组患者的升白疗效、外周血白细胞计数、T细胞亚群指标、生活质量评分,并进行安全性评价。结果两组患者治疗4周后的升白疗效比较,差异有统计学意义(P<0.05)。治疗2周及治疗4周后,试验组患者的外周血白细胞计数均高于对照组,差异有统计学意义(P<0.05)。治疗4周后试验组患者的CD3+、CD4+、CD4+/CD8+均高于对照组,差异有统计学意义(P<0.05)。治疗4周后两组患者的KPS评分均较治疗前升高,且试验组高于对照组,差异有统计学意义(P<0.05)。两组患者治疗前后安全性指标及不良反应比较,差异无统计学意义(P>0.05)。结论八珍颗粒治疗抗结核药相关性白细胞减少升白效果明显,外周血白细胞计数增高,T细胞亚群改善,可患者生活质量提高,值得临床推广。
Objective To explore the clinical efficacy and safety of Bazhen Granules in the treatment of anti-tuberculosis drug-related leukopenia.Methods A total of 288 patients with pulmonary tuberculosis were selected and divided into experimental group and control group according to the random number table method,with 144 cases in each group.Both groups of patients were given regular anti-tuberculosis treatment.In addition,patients in the experimental group were given Bazhen Granules orally,1 pack per dose for 2 doses/day;patients in the control group were given placebo orally,1 pack/dose for 2 doses/day.After 4 weeks of treatment,the effect of white blood cell increase,peripheral white blood cell count,T cell subset index,and quality of life score were compared between the two groups,and safety evaluation was carried out.Results The difference in the effect of white blood cell increase after 4 weeks of treatment was statistically significant between the two groups of patients(P<0.05).After 2 weeks of treatment and 4 weeks of treatment,the peripheral blood leukocyte counts in the experimental group were higher than those in the control group,and the difference was statistically significant(P<0.05).After 4 weeks of treatment,the CD3+,CD4+,CD4+/CD8+in the experimental group were higher than those in the control group,and the difference was statistically significant(P<0.05).After 4 weeks of treatment,the KPS scores in the two groups were higher than those before treatment,and the experimental group was higher than the control group.The difference was statistically significant(P<0.05).There were no statistically significant differences in safety indicators and adverse reactions between the two groups before and after treatment(P>0.05).Conclusion Bazhen Granules in the treatment of anti-tuberculosis drug-related leukopenia have significant effects on increasing white blood cell,increasing peripheral white blood cell count,improving T cell subset,and enhancing patients'quality of life,which is worthy of clinical promotion.
作者
胡雪
甄利波
HU Xue;ZHEN Libo(Department of Occupational Medicine,Hangzhou Hospital of Occupational Disease Prevention and Treatment,Hangzhou 310000,China;Department of Tuberculosis,Zhejiang Chinese Medicine and Western Medicine Integrated Hospital,Hangzhou310003,China)
出处
《中国现代医生》
2020年第29期110-113,共4页
China Modern Doctor
基金
浙江省中医药科技计划项目(2017ZKL015)
关键词
八珍颗粒
结核
白细胞减少
T细胞亚群
细胞免疫
Bazhen Granules
Tuberculosis
Leukopenia
T cell subset
Cell-mediated immunity
