摘要
虽然随着介入技术的发展,及时的再灌注治疗降低了急性心肌梗死的死亡率,但心梗后心脏的缺血再灌注损伤及不良重构,导致患者发生慢性心力衰竭,生活质量急剧下降,对社会经济造成了严重的负担。所以如何预防心肌梗死和改善心梗后缺血损伤及不良重构引起的心力衰竭,提高患者预后及生存质量成了新的热门研究话题。
Myocardial infarction(MI)is one of the leading causes of death worldwide.One of the primary rea⁃sons is that the rupture of atherosclerotic plaque leads to the formation of thrombosis,and then interrupts the coronary blood flow,thus finally causing the death of myocardial cells and cardiac dysfunction.A large number of researches have revealed that dendritic cells(DCs)play an essential role in immune inflammatory responses in the occurrence and develop⁃ment of atherosclerosis and MI.This article reviews the role of DCs in atherosclerosis,myocardial ischemia/reperfusion in⁃jury and cardiac remodeling after MI,and shows the potential values of DCs as an immunotherapeutic strategy for MI.
作者
张右铭
刘海波
ZHANG You-ming;LIU hai-bo(Department of Cardiology,Shanghai East Hospital,Tongji University,Shanghai 200120,China;Department of Cardiology,Qingpu Branch of Zhongshan Hospital,Fudan University,Shanghai 201700,China)
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2020年第11期2093-2098,共6页
Chinese Journal of Pathophysiology
基金
国家自然科学基金资助项目(No.81770350)。
关键词
树突状细胞
心肌梗死
动脉粥样硬化
缺血再灌注损伤
心肌重构
Dendritic cells
Myocardial infarction
Atherosclerosis
Ischemia/reperfusion injury
Myocar⁃dial remodeling
