摘要
鱼类肠道紧密连接结构是肠道黏膜屏障的重要组成。紧密连接在相邻的上皮细胞之间形成了由跨膜蛋白[如闭合蛋白(Claudin)和闭锁蛋白(Occludin)]和胞质蛋白[如闭锁小带蛋白-1(ZO-1)]所维持的复杂蛋白质结构,其中胞质紧密连接蛋白ZO-1属于膜相关鸟苷酸激酶(MAGUK)家族,是紧密连接的重要组成蛋白质之一。ZO-1在维持细胞极性和紧密连接屏障功能上发挥着重要作用,也与肠道疾病的发生有着密切联系。众所周知,ZO-1的表达在相当程度上受饲料营养素的影响和调节。因此,本文综述了饲料中蛋白质、脂肪、糖类、维生素和矿物质五大营养素对鱼类肠道紧密连接蛋白ZO-1的影响及作用机制的研究进展,这对于保持鱼类肠道屏障的功能稳定和提高饲料的利用效率有重要意义。
The intestinal tight junction structure of fish is an important component of intestinal mucosal barrier.Tight junction forms complex protein structure maintained by transmembrane proteins(eg. Claudin and Occludin)and cytoplasmic proteins[eg. zonula occludens-1(ZO-1)]between adjacent epithelial cells. Cytoplasmic tight junction protein ZO-1 is a member of the membrane associated guanosine kinase(MAGUK)family,it is one of the most important proteins in tight junction. ZO-1 plays an important role in maintaining cell polarity and tight junction barrier function,which is closely related to the occurrence of intestinal diseases. As it was known,the nutrients in diet can affect and regulate the expression of ZO-1 to some extent. Therefore,the review presents the effects of the five nutrients,such as protein,fat,carbohydrate,vitamins and minerals,on intestinal tight junction protein ZO-1 and the potential mechanism in fish,which will be helpful to maintain the integrity of fish intestinal barrier and improve the feed utilization efficiency.
作者
孔瑶瑶
马秀华
麦康森
张彦娇
KONG Yaoyao;MA Xiuhua;MAI Kangsen;ZHANG Yanjiao(Key Laboratory of Aquaculture Nutrition and Feeds,Ministry of Agriculture,Key Laboratory of Mariculture Ministry of Education,Ocean University of China,Qingdao 266003,China;Laboratory for Marine Fisheries Science and Food Production Processes,Qingdao National Laboratory for Marine Science and Technology,Qingdao 266237,China)
出处
《动物营养学报》
CAS
CSCD
北大核心
2020年第11期5081-5088,共8页
CHINESE JOURNAL OF ANIMAL NUTRITION
基金
国家自然科学基金(31872577)
青岛海洋科学与技术试点国家实验室海洋渔业科学与食物产出过程功能实验室渔业科技青年人才计划(2018-MFS-T10)
国家海水鱼产业技术体系(CARS 47-G10)。
