摘要
目的:分析复方甘草酸苷联合依巴斯汀治疗面部激素依赖性皮炎(HDD)对血清白细胞介素(IL-4)水平及皮肤屏障功能的影响。方法:选择笔者医院收治的100例面部HDD患者,随机分为对照组与治疗组,每组50例。对照组采用依巴斯汀治疗,治疗组采用复方甘草酸苷联合依巴斯汀治疗,比较两组临床疗效、皮损面积、血清生化指标、皮肤屏障功能、不良反应及随访情况差异。结果:经治疗,治疗组临床总有效率为84%,显著高于对照组的62%(P<0.05);治疗后,两组皮损面积呈明显下降趋势,组内差异显著(P<0.05);治疗组治疗2、3、4周时的皮损面积均显著小于对照组(P<0.05);治疗后,两组血清生化指标[IL-4、免疫球蛋白-E(IgE)及干扰素-γ(IFN-γ)]水平均显著降低(P<0.05),且治疗组的I L-4、I g E及I N F-γ水平均显著低于对照组(P<0.05);治疗后,两组局部皮肤屏障功能中油脂水平显著提高(P<0.05),经皮水分丢失值(TEWL)、红斑量显著降低,且治疗组的油脂水平显著高于对照组(P<0.05),TEWL、红斑量显著低于对照组(P<0.05);治疗期间,两组不良反应发生率比较差异无统计学意义(P>0.05),停药后4周随访,治疗组复发率显著低于对照组(P<0.05)。结论:复方甘草酸苷联合依巴斯汀治疗面部HDD疗效显著,可快速缩小皮损面积,改善患者炎症状态、免疫功能及皮肤屏障功能,复发率低,值得临床推广。
Objective To analyze the effects of compound glycyrrhizin combined with ebastine on serum interleukin(IL-4)level and skin barrier function in patients with facial hormone-dependent dermatitis(HDD).Methods 100 patients with facial HDD admitted to our hospital were selected and randomly divided into control group and treatment group,with 50 cases in each group.Control group was given ebastine,and treatment group was given compound glycyrrhizin combined with ebastine.The clinical efficacy,skin lesion area,serum biochemical markers,skin barrier function,adverse reactions and follow-up condition were compared between the two groups.Results After treatment,the total clinical effective rate in treatment group was signifi cantly higher than that in control group(84%vs 62%)(P<0.05).After treatment,the skin lesion area in the two groups showed a signifi cant downward trend(P<0.05).The skin lesion area at 2,3 and 4 weeks of treatment in treatment group was signifi cantly lower than that in control group(P<0.05).After treatment,the levels of serum biochemical markers[IL-4,immunoglobulin-E(IgE)and interferon-γ(IFN-γ)]were signifi cantly decreased in the two groups(P<0.05),and the levels of IL-4,IgE and INF-γin treatment group after treatment were signifi cantly lower than those in control group(P<0.05).After treatment,the grease level in skin barrier function was signifi cantly increased in the two groups(P<0.05)while the transepidermal water loss(TEWL)and erythema dose were significantly decreased,and the grease level in treatment group after treatment was signifi cantly higher than that in control group(P<0.05)while the TEWL and erythema dose were signifi cantly lower than those in control group(P<0.05).There was no signifi cant difference in the incidence rate of adverse reactions between the two groups during treatment(P>0.05).At 4w follow-up after withdrawal,the recurrence rate in treatment group was signifi cantly lower than that in control group(P<0.05).Conclusion Compound glycyrrhizin combined with ebastine has signifi cant efficacy in the treatment of facial HDD.And it can rapidly reduce the skin lesion area,improve the inflammatory states,immune function and skin barrier function of patients,and it has a low recurrence rate,thus it is worthy of clinical promotion.
作者
沈秀兰
SHEN Xiu-lan(Department of Dermatology,the First Hospital of Danjiangkou,Danjiangkou 442700,Hubei,China)
出处
《中国美容医学》
CAS
2020年第11期66-69,共4页
Chinese Journal of Aesthetic Medicine
