摘要
目的探讨以江苏省为主的区域性宫颈鳞癌患者单一人乳头瘤病毒(HPV)感染型别分布和发病年龄的临床意义。方法回顾性分析1978年11月至2019年6月的32家区域性医院的病理组织学诊断为宫颈鳞癌患者1125例资料,从宫颈鳞癌石蜡组织中提取HPV DNA,采用聚合酶链式反应与基因芯片检测技术对患者的癌组织行23种HPV检测,检出单一HPV感染型别患者851例,并对其主要单一HPV感染型别及患者的发病年龄进行分析。结果851例宫颈鳞癌患者的主要单一HPV型别感染率依次为16型(69.80%)、18型(7.52%)、58型(5.99%)、52型(3.53%)、33型(3.41%)、31型(3.29%)、59型(2.35%)和45型(1.06%),各主要单一HPV型别感染患者的平均年龄依次是58型为66.57岁、52型为66.27岁、31型为56.93岁、33型为56.69岁、59型为55.70岁、18型为52.23岁、16型为50.76岁。结论不同的单一HPV型别致宫颈鳞癌的风险度不同,其年龄分布也不同,了解其规律有助于临床医师更好地对HPV感染患者的患癌风险进行个体化预判。单一16型的致癌高峰年龄段为40~49岁,而单一58型的致癌高峰年龄段为70~79岁。
Objective To investigate the infection types distribution and onset ages of clinical significance of single human papillomavirus(HPV)genetypes in cervical squamous cell carcinoma(CSCC)cases within regional(mainly in Jiangsu Province).Methods We collected paraffin tissue samples from 1125 cases of the female′s cervical squamous cell carcinoma.DNA of HPV was extracted,then via the combination of gene-chip and polymerase chain reaction technology,23 genotypes of HPV were detected.We analyzed the types and ages state of single HPV infection types in 851 cases of cervical squamous cell carcinoma.Results Among 851 cases of CSCC,the major genetypes of single HPV types were successively HPV 16(69.80%),HPV 18(7.52%),HPV 58(5.99%),HPV 52(3.53%),HPV 33(3.41%),HPV 31(3.29%),HPV59(2.35%),HPV45(1.06%).The average ages were successively 66.57 year(58 type),66.27 year(52 type),56.93 year(31type),56.69 year(33 type),55.70 year(59 type),52.23 year(18 type),50.76 year(16 type)in the major single HPV infection types of 851 cases.Conclusion The degree of carcinogenic risk of various singular HPV types is different,and the age distribution of various singular HPV types is different as well in cases of CSCC.The carcinogenic peak of age group is 40-49 years in singular type HPV 16,while the carcinogenic peak of age group is 70-79 years in singular type HPV 58.
作者
陈晔
黄健
耿建祥
蔡博
李淑锋
顾冬梅
仇玮
候进军
赵雪
CHEN Ye;HUANG Jian;GENG Jian-xiang;CAI Bo;LI Shu-feng;GU Dong-mei;QIU Wei;HOU Jin-jun;ZHAO Xue(Department of Obstetrics and Gynecology,Wuxi Branch of Zhongda Hospital Affiliated to Southeast University,Wuxi 214001,Jiangsu,China;Shanghai Centre of Systems Biomedicine,Shanghai Jiao Tong University,Shanghai 200240,China;Department of Pathology,Nanjing Transitional Chinese Medical Hospital Affliated to Nanjing University of Chinese Medicine,Nanjing 210022,Jiangsu,China)
出处
《东南国防医药》
2020年第6期581-586,共6页
Military Medical Journal of Southeast China
基金
上海市卫生和计划生育委员会科研课题(201840340)。
