摘要
【目的】在补土理论指导下,应用升陷固脾汤治疗克罗恩病,旨在探讨升陷固脾汤对克罗恩病患者体质量的影响。【方法】回顾性分析广东省中医院炎症性肠病慢病门诊2015年10月至2016年2月收治的20例克罗恩病患者,在维持原有西药治疗方案基础上,给予升陷固脾汤加减治疗,疗程为24个月。比较治疗前和治疗6、12、18、24个月后患者的简化克罗恩病活动指数(CDAI)评分与人体成分分析各项指标的变化情况。【结果】(1)克罗恩病患者使用升陷固脾汤治疗12、18、24个月后,随着治疗时间延长,简化CDAI评分逐渐下降,并在治疗24个月后差异有统计学意义(P<0.05)。(2)人体成分分析方面,经升陷固脾汤治疗后,患者的去脂体质量、细胞总水分、细胞内液与外液总量、蛋白质含量、矿物质含量、肌肉含量、骨骼肌含量、骨无机盐含量、基础代谢率、身体细胞数量、颈围、胸围、臀围、左臂肌围、右臂肌围、左下肢电阻抗、右下肢电阻抗、四肢相位角及全身相位角等指标均在不同时段中得到改善,差异均有统计学意义(P<0.05)。【结论】升陷固脾汤治疗克罗恩病患者疗效确切,能有效缓解患者症状和改善患者体质量。
Objective Under the guidance of the theory of invigorating earth(invigorating spleen),Shengxian Gupi Decoction was used for the treatment of Crohn’s disease,and its effect on the body mass of patients with Crohn’s disease was also observed.Methods A retrospective analysis was carried out in 20 cases of Crohn’s disease in the chronic disease outpatient department of inflammatory bowel diseases in Guangdong Provincial Hospital of Traditional Chinese Medicine from October of 2015 to February of 2016.The 20 patients with Crohn’s disease were given oral use of modified Shengxian Gupi Decoction based on the initial western medicine treatment for 24 months.We compared the changes in the scores of simplified Crohn’s disease activity index(CDAI)and body composition analysis indicators before treatment,and after treatment for 6,12,18,and 24 months.Results(1)After treatment with Shengxian Gupi Decoction for 12,18,and 24 months,the scores of simplified CDAI of the patients with Crohn’s disease were decreased with the prolongation of the course of treatment,and the simplified CDAI scores after treatment for 24 months differed from those before treatment(P<0.05).(2)In respect of the body composition analysis indicators,obvious improvement was achieved in the body composition analysis indicators of defatted body weight,total cell moisture,total intracellular and extracellular fluid,protein content,mineral content,muscle content,skeletal muscle content,bone inorganic salt,basic metabolic rate,quantity of body cells,neck circumference,chest circumference,hip circumference,left arm muscle circumference,right arm muscle circumference,left lower extremity electrical impedance,right lower extremity electrical impedance,limb phase angle and whole body phase angle in the patients with Crohn’s disease at various periods after treatment by Shengxian Gupi Decoction,and the differences were statistically significant(P<0.05).Conclusion Shengxian Gupi Decoction exerts certain effect for the treatment of patients with Crohn’s disease through effectively relieving the symptoms and improving the body mass.
作者
胡锦辉
黄智斌
陈延
HU Jin-Hui;HUANG Zhi-Bin;CHEN Yan(The Second Clinical Medical School of Guangzhou University of Chinese Medicine,Guangzhou 510405 Guangdong,China;Famous Physician Studio of the Second Affiliated Hospital,Guangzhou University of Chinese Medicine,Guangzhou 510120 Guangdong,China;Dept.of Digestive Diseases,Fangcun Branch of the Second Affiliated Hospital,Guangzhou University of Chinese Medicine,Guangzhou 510370 Guangdong,China)
出处
《广州中医药大学学报》
CAS
2020年第12期2313-2319,共7页
Journal of Guangzhou University of Traditional Chinese Medicine
基金
广东省中医院院内专项补土流派工作室项目(编号:2013KT1516)。
关键词
补土理论
克罗恩病
升陷固脾汤
人体成分分析
回顾性分析
theory of invigorating earth(invigorating spleen)
Crohn’s disease
Shengxian Gupi Decoction
body composition analysis
retrospective analysis
