摘要
早在40年前就在细胞中发现N6-甲基腺苷(m6A)。但是,m6A修饰的功能和相关调控蛋白近几年才陆续揭晓。m6A是真核生物mRNA中最丰富的化学修饰之一,最近研究发现m6A在各种正常生物过程中发挥重要作用。现结合近年来的研究报道论述m6A在干细胞分化、肿瘤产生和病毒感染方面的生物学功能,为表观转录组学的相关研究提供参考。
N6-methyladenosine(m^6 A) was found in cells as early as 40 years ago.However,the functions of m^6A modification and regulatory enzymes have been revealed in recent years.m^6A is one of the most abundant chemical modifications in eukaryotic mRNA.Recent studies have found that m^6A plays an important role in various normal biological processes.In this review,we mainly introduce the biological functions of m^6A in stem cell differentiation,tumorigenesis and viral infection,which provides reference for epitranscriptomic research.
作者
罗颖
郑青
房师松
LUO Ying;ZHENG Qing;FANG Shi-song(College of Pharmacy,Jinan University,Guangzhou,Guangdong 510632;Shenzhen Center for Disease Control and Prevention,Shenzhen,Guangdong 518055,China)
出处
《热带医学杂志》
CAS
2020年第9期1254-1258,共5页
Journal of Tropical Medicine
基金
国家自然科学基金(81871631)
深圳市科技计划项目(JCYJ20170306160244540)
深圳市卫生计生系统科研项目(201602002)
广东省医学科研基金(A2018269)。
关键词
RNA修饰
6-甲基腺嘌呤
干细胞
肿瘤
病毒
RNA modification
6-methyladenine
Stem cell differentiation
Tumorigenesis
Virus infection
