摘要
目的分析拉萨地区不同民族表观健康人群的同型半胱氨酸(HCY)水平及其影响因素,初步建立参考区间。方法参考区间建立。分析西藏自治区人民医院2018年1月至12月820名表观健康体检人群血清HCY(μmol/L)水平,将全部人群按照民族、性别、年龄、季节分组,使用一般线性模型分析民族、性别、年龄、季节组别中血清HCY水平的差异。依据CLSI C28文件,使用Nested ANOVA和Z检验分析并确定临床应用中是否需要分组建立参考区间。结果经一般线性模型分析民族、年龄、性别对血清HCY存在显著影响,其中藏族HCY水平高于汉族(P<0.001);男性HCY水平高于女性(P<0.001);50岁以上人群HCY水平高于50岁以下人群(P=0.01),血清HCY水平在季节分布上差异无统计学意义(P=0.22)。Nested ANOVA和Z检验确定临床应用中需要依据民族和性别建立拉萨地区HCY的参考区间。其中,藏族男性的HCY参考区间为<22.41μmol/L,藏族女性HCY的参考区间为<18.41μmol/L。结论拉萨地区表观健康人群血清HCY水平在不同民族、性别、年龄人群中略有差异,本研究成功建立了西藏地区藏族男性和藏族女性的HCY参考区间。
Objective To analyze the level of homocysteine(HCY)and its influencing factors in different ethnic groups in Lhasa,and to explore its reference interval.Methods Reference interval study.The serum HCY(μmol/L)level of 820 healthy subjects was analyzed in Tibet autonomous region People′s hospital from January to December 2018.All the subjects were divided into groups according to ethnicity,gender,age and season.The general linear model was used to analyze the differences in serum HCY levels groups.According to the CLSI C28 document,the Nested ANOVA and Z test were used to analyze and determine whether or not different groups need to establish the reference interval.Results Ethnicity,age and gender had significant effects on serum HCY.The level of HCY in Tibetan was higher than that in Han(P<0.001);the level of Hcy in male was higher than that in female(P<0.001);the level of HCY in over-50 year old group was higher than that in under-50 year old group(P=0.01).There was no significant difference in serum HCY level in seasonal distribution(P=0.22).Nested ANOVA and Z tests confirmed that the HCY reference interval in Lhasa should be established according to ethnicity and gender in clinical application.The reference interval of HCY level in Lhasa area was established according to difference genders,including<22.41μmol/L for Tibetan men,<18.41μmol/L for Tibetan women.Conclusions The serum HCY levels of the apparent healthy people in Lhasa area were slightly different among people of different ethnicities,genders and ages.We established the reference intervals of HCY of different ethnic groups and gender groups in Tibet and our results have practical significance for the prevention and treatment of cardiovascular and cerebrovascular diseases at high altitude.
作者
旦曲
米玛顿珠
普芝
刘治娟
格桑罗布
刘焕东
程歆琦
Dan Qu;Mima Dunzhu;Pu Zhi;Liu Zhijuan;Gesang Luobu;Liu Huandong;Cheng Xinqi(Department of laboratory Medicine,Tibet autonomous region People′s hospital,Lhasa 850000,China;Department of Neurology,Tibet autonomous region People′s hospital,Lhasa 850000,China;Institute of Altitude sickness,Tibet autonomous region People′s hospital,Lhasa 850000,China;Department of Neurosurgery,Tibet autonomous region People′s hospital,Lhasa 850000,China;Department of laboratory Medicine,Peking union medical college hospital,Peking 100730,China)
出处
《中华检验医学杂志》
CAS
CSCD
北大核心
2020年第10期1002-1007,共6页
Chinese Journal of Laboratory Medicine
