摘要
目的观察瑞舒伐他汀联合硫酸氢氯吡格雷治疗对冠状动脉粥样硬化性心脏病(简称冠心病)患者心功能的影响。方法选取2018年3月-2019年3月麻城市人民医院收治的冠心病患者120例为研究对象,采取随机数字表法分为试验组和对照组,每组60例。在常规治疗基础上,对照组给予硫酸氢氯吡格雷治疗,试验组给予瑞舒伐他汀联合硫酸氢氯吡格雷治疗,比较2组治疗效果、治疗前后心功能指标变化情况。结果治疗2个月后,试验组总有效率为91.67%,高于对照组的75.00%(χ2=6.000,P=0.014);治疗2个月后,2组左室射血分数(LVEF)较治疗前升高,左心房内径(LAD)、左室舒张末期内径(LVEDD)均较治疗前缩小,且试验组升高或缩小幅度大于对照组(P <0.01)。结论与单一应用硫酸氢氯吡格雷治疗相比,瑞舒伐他汀联合硫酸氢氯吡格雷治疗冠心病患者的效果更好,可明显改善患者心功能指标,具有临床推广应用价值。
Objective To study the effects of rosuvastatin combined with clopidogrel bisulfate on heart function in patients with coronary heart disease. Methods 120 patients with coronary heart disease admitted to Macheng people’s Hospital from March 2018 to March 2019 were selected as the research objects and randomly divided into experimental group and control group,with 60 cases in each group. On the basis of conventional treatment,the control group was treated with clopidogrel bisulfate,and the experimental group was treated with rosuvastatin combined with clopidogrel bisulfate. The treatment effects and changes of heart function indexes before and after treatment were compared between the two groups. Results After2 months of treatment,the total effective rate of the experimental group was 91. 67%,which was higher than 75. 00% of the control group( χ~2= 6. 000,P = 0. 014);the left ventricular ejection fraction( LVEF) was higher than before treatment,left atrial inner diameter( LAD) and left ventricular end diastolic diameter( LVEDD) were shrinker than before treatment,and the increase or decrease in the experimental group was greater than that in the control group( P < 0. 01). Conclusion Compared with single drug treatment,rosuvastatin combined with clopidogrel bisulfate in the treatment of coronary heart disease has a better effect on improving heart function. After treatment,relevant indicators of patients have been significantly improved,which has clinical application value.
作者
彭晓光
PENG Xiaoguang(Department of Medical T Mache eg People's Hospital,Hubei Province,Macheng 438300,China)
出处
《临床合理用药杂志》
2020年第26期3-5,共3页
Chinese Journal of Clinical Rational Drug Use
