摘要
目的分析tRNA天冬氨酸甲基转移酶1(TRDMT-1)、癌胚抗原相关细胞黏附分子-1(CEACAM-1)在结直肠癌中的表达及与肿瘤生物学特性的相关性。方法收集62例结直肠癌患者的临床资料,同选取本组患者距离肿瘤组织<5 cm的正常组织肠黏膜组织作为参照,对比TRDMT-1、CEACAM-1不同表达微淋巴管密度(LMVD)的差异,分析影响结直肠癌患者预后死亡的危险因素。结果结直肠癌的TRDMT-1、CEACAM-1阳性表达率分别为61.29%、64.52%;癌旁正常组织分别为27.42%、30.65%,明显低于结直肠癌组织,且结直肠癌组织中的LMVD值亦显著高于癌症正常组织(t=22.976,P<0.05)。结直肠癌组织中TRDMT-1、CEACAM-1表达均与肿瘤浆膜浸润、TNM分期、肝转移、淋巴结转移、脉管浸润有关(P<0.05),而TRDMT-1表达与肿瘤直径、组织学分化程度关系密切(P<0.05)。结直肠癌组织中TRDMT-1、CEACAM-1阳性表达者LMVD值均显著高于TRDMT-1、CEACAM-1阴性表达者(P<0.05)。非条件多因素Logistic回归分析结果示,TRDMT-1、CEACAM-1阳性表达是影响结直肠癌患者预后死亡的危险因素(P<0.05)。结论 TRDMT-1、CEACAM-1的高表达及LMVD的升高与结直肠癌的生物学行为和进展关系密切,临床上可根据TRDMT-1、CEACAM-1表达情况对患者进行病情评估、预后监测。
Objective To analyze the expression of tRNA aspartic acid methyltransferase1(TRDMT-1),carcinoembryonic antigen-related cell adhesion molecule-1(CEACAM-1)in colorectal cancer and its correlation with tumor biological characteristics.Method The clinical data of 62 patients with colorectal cancer were selected.The normal intestinal mucosal tissues less than 5 cm from the tumor tissue of patients in this group were selected as a reference.The differences in lymphatic micro-vessel density(LMVD)of patients with different expressions of TRDMT-1 and CEACAM-1 were compared,and risk factors affecting the prognosis of patients with colorectal cancer were analyzed.Results The positive expression rates of TRDMT-1 and CEACAM-1 in colorectal cancer were 61.29%and 64.52%,respectively.The positive expression rates of TRDMT-1 and CEACAM-1 in normal tissues adjacent to cancer were 27.42%and 30.65%,respectively,which were significantly lower than those in colorectal cancer tissues,and the LMVD value in colorectal cancer tissues was also significantly higher than that in normal cancer tissues(t=22.976,P<0.05).The expressions of TRDMT-1 and CEACAM-1 in colorectal cancer tissues were related to tumor serous infiltration,TNM staging,liver metastasis,lymph node metastasis,and vascular invasion(P<0.05).The expression of TRDMT-1 was closely related to the tumor diameter and the degree of histological differentiation(P<0.05).The LMVD values of patients with positive expression of TRDMT-1 and CEACAM-1 in colorectal cancer were significantly higher than those with negative expression of TRDMT-1 and CEACAM-1(P<0.05).Unconditional multivariate logistic regression analysis showed that the positive expressions of TRDMT-1 and CEACAM-1 were the risk factors affecting the death prognosis of patients with colorectal cancer(P<0.05).Conclusion The high expression of TRDMT-1 and CEACAM-1 and the increase of LMVD are closely related to the biological behavior and progression of colorectal cancer.Clinically,patients can be evaluated and monitored for prognosis based on the expression of TRDMT-1 and CEACAM-1.
作者
冯婧
赵凯
周鑫
FENG Jing;ZHAO Kai;ZHOU Xin(Department of Gastroenterology,Jintan People's Hospital Of Jiangsu University,Jintan,Jiangsu,213200)
出处
《分子诊断与治疗杂志》
2020年第11期1556-1560,共5页
Journal of Molecular Diagnostics and Therapy
基金
江苏省科技厅社会发展面上项目(BE2017592)。
