摘要
目的检测不同严重程度慢性阻塞性肺疾病(COPD)患者右心功能状态,探讨应用Tei指数和N端脑利钠肽前体(NT-proBNP)共同评价COPD患者右心功能状况的临床价值。方法选取60例稳定期COPD患者,根据慢性阻塞性肺疾病全球创议(GOLD)肺功能分级将其分为GoldⅠ级组(n=16)、GoldⅡ级组(n=24)、GoldⅢ级组(n=12)、GoldⅣ级组(n=8)。选择同期健康体检者20例作为对照组。均行超声心动图检测出Tei指数及测定血浆NT-proBNP水平。结果GoldⅡ、Ⅲ、Ⅳ级组Tei指数均高于对照组,差异均有统计学意义(P<0.05)。Tei指数随着GOLD分级升高而升高(P<0.05);GoldⅡ、Ⅲ、Ⅳ级组NT-proBNP水平均高于对照组,差异均有统计学意义(P<0.05)。NT-proBNP水平随着GOLD分级升高而升高。除GoldⅡ级组与GoldⅢ级组比较差异无统计学意义(P>0.05),其余各组均有统计学意义(P<0.05)。分别对Tei指数与FEV1%、FEV1/FVC进行相关性分析,二者均呈负相关(r=-0.914、-0.799,P<0.01)。Tei指数与NT-proBNP呈正相关(r=0.854,P<0.01)。结论Tei指数和NT-proBNP均可对COPD患者评估右心功能,二者联合可以为COPD患者右心功能损害的早期诊断提供参考。
Objective To investigate the clinical value of Tei index and NT-proBNP in evaluating the right heart function of patients with COPD at different degree of disease severity.Methods A total of 60 patients with stable COPD were enrolled in the study.According to global obstructive pulmonary disease Disease initiative(GOLD)pulmonary functional classification,these patients were divided into GoldⅠgroup(n=16),GoldⅡgroup(n=24),GoldⅢgroup(n=12)GoldⅣgroup(n=8).Moreover the other 20 healthy subjects were enrolled as control group.Tei index was detected by echocardiography,and the plasma levels of NT-proBNP were detected.Results The Tei indexes in GoldⅡgroup,GoldⅢgroup and GoldⅣgroup were significantly higher than those in control group(P<0.05).The Tei indexes were increased with the increase of GOLD grade(P<0.05).Moreover the plasma levels of NT-proBNP in GoldⅡgroup,GoldⅢgroup and GoldⅣgroup were significantly higher than those in control group(P<0.05),and the plasma levels of NT-proBNP were increased with the increase of GOLD grade(P<0.05).In addition there were significant differences among groups each other(P<0.05)except for GoldⅡgroup vs GoldⅢgroup(P>0.05).Furthermore the Tei index was negatively correlated with FEV1%and FEV1/FVC(P<0.01),however,which was positivelt correlated with NT-proBNP(P<0.01).Conclusion Both Tei index and NT-proBNP can be used to evaluate the right cardiac function in patients with COPD.The combination of the two indexes can provide reference for the early diagnosis of right cardiac function impairment in patients with COPD.
作者
李岚
姜芳
史金英
宋宁
刘荣惠
LI Lan;JIANG Fang;SHI Jinying(Department of Respiratory Medicine,People’s Hospitial of Shijiazhuang City,Hebei,Shijiazhuang 050031,China)
出处
《河北医药》
CAS
2020年第22期3421-3423,3427,共4页
Hebei Medical Journal
基金
石家庄市科学技术局科技支撑计划(编号:171461253)。
关键词
慢性阻塞性肺疾病
TEI指数
N端脑利钠肽前体
肺功能
心功能
chronic obstructive pulmonary disease
Tei index
N-terminal pro-brain natriuretic peptide
lung function
heart function
