摘要
目的分析新生儿血培养细菌的分布情况,并统计耐药情况。方法方便选取该院自2016年1月-2018年12月进行血培养的1854例新生儿作为研究对象,分离出309株病原菌,统计血培养细菌分布情况,并进行药敏试验,分析耐药情况。结果血培养阳性新生儿1854例中分离出309株的病原菌,其中2016年新生儿分离出40株,2017年新生儿分离出60株,2018年分离出209株;菌类占比最高的前5位依次为无乳链球菌(B群)、大肠埃希菌、表皮葡萄球菌、粪肠球菌、咽颊炎链球菌。无乳链球菌(B群)对常见的10种抗菌药物耐药率占比最高的前3位依次为苄青霉素(100.00%)、红霉素(73.77%)、克林霉素(59.02%);表皮葡萄球菌对常见的10种抗菌药物耐药率占比最高的前3位依次为苄青霉素(100.00%)、红霉素(100.00%)、环丙沙星(89.29%);粪肠球菌对常见的10种抗菌药物耐药率占比最高的前3位依次为克林霉素(100.00%)、四环素(86.96%)、红霉素(65.22%)。大肠埃希菌对常见的10种抗菌药物耐药率占比最高的前3位依次为氨苄西林(82.69%)、头孢唑林(55.77%)、头孢曲松(50.00%);肺炎克雷伯菌对常见的10种抗菌药物耐药率占比最高的前3位依次为头孢曲松(100.00%)、氨苄西林(100.00%)、头孢唑林(100.00%)。结论根据新生儿血培养结果和耐药情况指导抗生素使用较为合理。
Objective To analyze the distribution of neonatal blood culture bacteria and to make statistics on drug resistance.Methods 1854 newborns who underwent blood culture in the hospital from January 2016 to December 2018 were conveniently selected as the research objects,309 pathogens were isolated,the distribution of blood culture bacteria was counted,and the drug sensitivity test was performed to analyze the drug resistance.Results 309 strains of pathogenic bacteria were isolated from 1854 cases of positive blood culture newborns.Among them,40 were isolated from newborns in2016,60 were isolated from newborns in 2017,and 209 were isolated in 2018;the proportion of bacteria was the highest.The top five are Streptococcus agalactiae(group B),Escherichia coli,Staphylococcus epidermidis,Enterococcus faecalis,and Streptococcus pharyngitis.Streptococcus agalactiae(group B)has the highest proportion of resistance to 10 common antimicrobials.The top three are benzylpenicillin(100.00%),erythromycin(73.77%),and clindamycin(59.02%).The top three with the highest rate of resistance to 10 common antimicrobials of Staphylococcus epidermidis were benzylpenicillin(100.00%),erythromycin(100.00%),and ciprofloxacin(89.29%);Enterococcus faecalis accounted the top three with the highest rate of resistance to 10 common antimicrobials were clindamycin(100.00%),tetracycline(86.96%),and erythromycin(65.22%).Escherichia coli has the highest proportion of resistance to 10 common antimicrobial drugs.The top three were ampicillin(82.69%),cefazolin(55.77%),ceftriaxone(50.00%);Kleber pneumoniae of the top three bacteria with the highest rate of resistance to 10 common antimicrobials are ceftriaxone(100.00%),ampicillin(100.00%),and cefazolin(100.00%).Conclusion It is reasonable to guide the use of antibiotics based on the results of neonatal blood culture and drug resistance.
作者
郑东伟
ZHENG Dong-wei(Department of Laboratory Medicine,Obstetrics and Gynecology Hospital,Zhejiang University School of Medicine,Hangzhou,Zhejiang Province,310002 China)
出处
《中外医疗》
2020年第31期53-56,共4页
China & Foreign Medical Treatment
关键词
新生儿
血培养
细菌分布
药敏试验
耐药
Newborn
Blood culture
Bacterial distribution
Drug sensitivity test
Drug resistance
