摘要
抑郁症是常见的情志病,对患者家庭及社会造成沉重的疾病负担,其发病机制目前尚不完全清楚,可能与炎症、神经递质、神经营养因子、海马神经元突触可塑性等有关。临床应用西药治疗抑郁症,存在副作用大,患者依从性差,有效率不高,停药后反弹等问题;中医治疗抑郁症具有副作用小,患者依从性高等特点。抑郁症属中医学"郁证"范畴,中医认为抑郁症主要症候有肝郁气滞、气郁化火、心脾两虚、心肺两虚、痰气郁结、肝肾不足等。半夏厚朴汤是载于汉代张仲景《金匮要略》的经典名方,有治疗痰气郁结型郁证的功效。本文通过检索中国知网(CNKI),中国生物医学文献数据库(CBM),万方数据,Pubmed,Embase,Web of Science等数据库中关于半夏厚朴汤治疗抑郁症的相关文献,发现临床应用和实验研究均提示,半夏厚朴汤有显著的抗抑郁作用。临床研究显示,半夏厚朴汤可改善抑郁症患者焦虑量表和抑郁量表得分,抗抑郁的疗效显著,且优势凸显;实验研究表明,半夏厚朴汤及其有效成分的抗抑郁作用可能与干预炎症反应、影响神经递质、调节神经营养因子、改善海马神经元突触可塑性、减少氧化应激等有关。故对半夏厚朴汤临床治疗的几种抑郁症类型以及半夏厚朴汤相关实验研究的文献进行综述。
Depression is a common emotional disease,causing a heavy burden of disease on patients’ families and society. Its pathogenesis is not yet fully understood,andmay be related to inflammation,neurotransmitters,neurotrophicfactors,hippocampal neuronal synaptic plasticity,oxidative stress,etc. Clinical application of Western medicine to treat depression has serious side effects,poor patient compliance,the effective rate is not high,rebound after withdrawal,etc. Traditional Chinese medicine treatment of depression has the characteristics of low side effects and high patient compliance. Depression belongs to the category of depression syndromein traditional Chinese medicine. Traditional Chinese medicine believes that the main symptoms of depression include depressed liver Qi,stagnated Qi transforming into fire,deficiency in heart and spleen,deficiency in heart and lung,stagnation of phlegm and Qi,deficiency of liver and kidney,etc. Banxia Houpu Tang is a classic recipe contained in "Synopsis of the Golden Chamber" by Zhang Zhongjing in the Han Dynasty,it has the effect of treating depression syndrome of stagnation of phlegm and Qi. By searching the literatures of Banxia Houpu Tang in the treatment of depression in Chinese knowledge network database(CNKI),Chinese biomedical literature database(CBM),Wanfang Data,Pubmed,Embase,Web of Science and other databases,we found that both clinical application and experimental research suggest that Banxia Houpu Tang has a significant antidepressant effect. Clinical studies have shown that Banxia Houpu Tang can improve the scores of anxiety scales and depression scales of patients with depression. The antidepressant effect is significant,and the advantages are prominent. Experimental research shows that the antidepressant effect of Banxia Houpu Tang and its effective components may be related to the factors such as intervention of inflammatory response,influence of neurotransmitters, regulation of neurotrophic factors, improvement of synaptic plasticity of hippocampal neurons and reduce oxidative stress,etc. Therefore,this paper reviews several types of depression in the clinical treatment of Banxia Houpu Tang and the related experimental studies of Banxia Houpu Tang.
作者
毛梦迪
尚立芝
许二平
MAO Meng-di;SHANG Li-zhi;XU Er-ping(Academy of Chinese Medical Sciences,School of Basic Medical Science,Henan University of Chinese Medicine,Zhengzhou 450046,China;Henan Key Laboratory for Modern Research of Zhongjing Compound Traditional Chinese Medicine,Zhengzhou 450046,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2020年第23期37-43,共7页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(81973739)
河南省高等学校重点科研项目(20B360011)
河南省科技攻关计划项目(172102310195)
河南省教育科学“十三五”规划一般课题(〔2019〕-JKGHYB-0101,〔2019〕-JKGHYB-0114)。
关键词
半夏厚朴汤
抑郁症
临床应用
实验研究
综述
Banxia Houpu Tang
depression
clinicalapplication
experimentalstudy
review
