摘要
目的探讨盐酸川芎嗪注射液联合替格瑞洛片治疗冠心病心绞痛的临床疗效。方法选取2018年6月—2020年2月天津市宁河区医院收治的104例冠心病心绞痛患者作为研究对象,按照随机数字表法将104例患者分为对照组和治疗组,每组各52例。对照组口服替格瑞洛片,90 mg/次,2次/d。治疗组患者在对照组治疗的基础上静脉滴注盐酸川芎嗪注射液,40mg/次,1次/d。15d为1个疗程,两组患者连续治疗2个疗程。观察两组患者的心绞痛疗效、心电图疗效,比较两组患者的心绞痛次数、发作持续时间、硝酸甘油用量、视觉模拟评分(VAS)、心功能指标和炎性因子白细胞介素-6(IL-6)、同型半胱氨酸(Hcy)、缺血修饰白蛋白(IMA)水平。结果治疗后,治疗组患者的心绞痛疗效、心电图疗效总有效率均高于对照组,两组间差异具有统计学意义,差异有统计学意义(P<0.05)。治疗后,两组患者的心绞痛次数、发作持续时间、硝酸甘油用量、VAS评分显著降低,差异均有统计学意义(P<0.05);治疗组患者在治疗后的心绞痛次数、发作持续时间、硝酸甘油用量、VAS评分均低于对照组,差异有统计学意义(P<0.05)。治疗后,两组的左心室射血分数(LVEF)、心输出量(CO)、每搏输出量(SV)均显著升高(P<0.05);治疗后治疗组的LVEF、CO、SV高于对照组(P<0.05)。治疗后,两组的IL-6、Hcy、IMA水平均显著降低(P<0.05);治疗后治疗组的IL-6、Hcy、IMA水平均低于对照组(P<0.05)。结论盐酸川芎嗪注射液联合替格瑞洛片可提高冠心病心绞痛的疗效,改善心绞痛症状,提高心功能,降低心肌的炎性损伤。
Objective To investigate the clinical effect of Ligustrazine Hydrochloride Injection combined with Ticagrelor Tablets in treatment of angina pectoris of coronary heart disease. Methods Patients(104 cases) with angina pectoris of coronary heart disease in Tianjin Ninghe Hospital from June 2018 to February 2020 were randomly divided into control and treatment groups, and each group had 52 cases. Patients in the control group were po administered with Ticagrelor Tablets, 90 mg/time, twice daily. Patients in the treatment group were iv administered with Ligustrazine Hydrochloride Injection on the basis of the control group, 40 mg/time, once daily. A course of treatment had 15 d, and patients in two groups were treated for 2 courses. After treatment, the effect of angina pectoris and ECG were evaluated, and the frequency and duration of angina pectoris, the dosage of nitroglycerin, and the VAS score, the cardiac function indexes, the levels of IL-6, Hcy, and IMA in two groups were compared. Results After treatment, the angina pectoris efficacy and ECG efficacy of the treatment group were higher than those of the control group, and the difference was statistically significant(P < 0.05). After treatment, the frequency and duration of angina pectoris, the dosage of nitroglycerin, and the VAS score of the two groups were significantly decreased, and the differences were statistically significant(P < 0.05). And the frequency and duration of angina pectoris, the dosage of nitroglycerin, and the VAS score of the treatment group were lower than those of the control group, and the difference was statistically significant(P < 0.05). After treatment, LVEF, CO, and SV of the two groups were significantly increased(P < 0.05). And after treatment, LVEF, Co, and SV of the treatment group were higher than those of the control group(P < 0.05). After treatment, the levels of IL-6, Hcy, and IMA in two groups were significantly decreased(P < 0.05). And after treatment, the levels of IL-6, Hcy, and IMA in the treatment group were lower than those in the control group(P < 0.05). Conclusion Ligustrazine Hydrochloride Injection combined with Ticagrelor Tablets can improve the effect of angina pectoris, improve the symptoms of angina pectoris, reduce the degree of inflammation, and improve the cardiac function.
作者
李莉
张海霞
LI Li;ZHANG Hai-xia(Department of Cardiovascular Medicine,Tianjin Ninghe Hospital,Tianjin 301500,China;Department of Ophthalmology,Tianjin Fifth Central Hospital,Tianjin 300450,China)
出处
《现代药物与临床》
CAS
2020年第10期1968-1972,共5页
Drugs & Clinic
基金
天津市滨海新区卫生计生委科技项目(2016BWKY018)。
关键词
盐酸川芎嗪注射液
替格瑞洛片
冠心病心绞痛
心绞痛次数
发作持续时间
视觉模拟评分法(VAS)
心功能指标
炎性因子
Ligustrazine Hydrochloride Injection
Ticagrelor Tablets
angina pectoris of coronary heart disease
frequency of angina pectoris
duration of angina pectoris
VAS score
cardiac function index
inflammatory factor
