摘要
呼吸困难是急性心力衰竭综合征(acute heart failure syndromes,AHFS)患者最常见的症状,缓解呼吸困难是临床实践、临床试验和新药审批中须关注的重要目标。然而,在临床和科研中,如何评估呼吸困难依然没有形成共识,目前尚缺乏统一的测量方法。本文将从急性心力衰竭呼吸困难的病理生理学机制、呼吸困难测量时间、测量时患者的体位、测量条件、临床试验中常见的呼吸困难测量方法及其优缺点等方面进行讨论,为急性心力衰竭临床试验中呼吸困难的测量方法选择提供参考。
Dyspnea is the most common symptom in patients with acute heart failure syndrome(AHFS),and relieving dyspnea is an important goal in clinical practice,clinical trials and new drug regulatory approval.However,in clinical and scientific research,there is still no consensus on how to evaluate dyspnea,and there is still a lack of unified measurement methods.This article introduces the pathophysiological mechanism of dyspnea in acute heart failure,the measuring time of dyspnea,the posture of patients during measurement,the measuring conditions,and the common measurement methods of dyspnea in clinical trials and their advantages and disadvantages,so as to provide references for the selection of measurement methods of dyspnea in clinical trials of acute heart failure.
作者
张晶晶
刘岩
张晓雨
陈莹
商洪才
ZHANG Jingjing;LIU Yan;ZHANG Xiaoyu;CHEN Ying;SHANG Hongcai(Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,P.R.China;Beijing University of Chinese Medicine,Beijing 100029,P.R.China)
出处
《中国循证医学杂志》
CSCD
北大核心
2020年第11期1334-1339,共6页
Chinese Journal of Evidence-based Medicine
基金
国家重点研发计划项目(编号:2017YFC1700400)。
