摘要
酒精是引起胃损伤的主要因素之一,酒精性胃损伤已成为全球性健康问题之一,严重影响人类生活质量。许多研究显示,中草药活性成分可有效减轻酒精引起的胃损伤。该文对近5年报道的抗酒精性胃损伤的中草药,按萜类、黄酮类、多酚类、多糖类、挥发油类、苯丙素类和生物碱类等分类,初步归纳了其活性成分及作用机制。萜类化合物可调控相关信号通路,改善氧化应激和炎症反应发挥作用,黄酮类化合物的作用机制主要与抗氧化和抗炎特性有关,多酚类化合物可调节参与炎症通路、氧化应激和细胞凋亡途径的相关因子水平,多糖类化合物可抑制氧化应激损伤和炎症反应、增强胃粘膜防御因子能力,苯丙素类化合物可增强胃黏膜防御因子能力,挥发油类可抑制H+/K+-ATP酶活性或炎症反应,生物碱类化合物可抑制炎症反应、改善抗氧化系统发挥作用。该文以期为抗酒精性胃损伤中草药的进一步研发提供参考。
Alcohol is considered to be one of the main causes for gastric injury, and alcoholic gastric injury has been becoming one of the global health problems, which seriously affects the quality of human life. Many studies suggest that the active components extracted from Chinese herbal medicine can effectively reduce the degree of alcohol-induced gastric injury. The active components and its mechanism of anti-alcoholic gastric injury of Chinese herbal medicine reported in recent five years were preliminarily summarized according to the classification of terpenoids, flavonoids, polyphenols, polysaccharides, volatile oils, phenylpropanoids and alkaloids in this paper. The terpenoids could improve oxidative stress and inflammatory response by regulating relevant signaling pathways. The flavonoids are mainly related to antioxidant and anti-inflammatory properties. The polyphenols mainly regulate the level of relevant factors involved in inflammatory pathway, oxidative stress and apoptosis pathway. The polysaccharides could enhance the ability of gastric mucosal defense factor by inhibiting oxidative stress injury and inflammatory response. Phenylpropanoids could enhance the gastric mucosal defense factor. The volatile oils mainly inhibit H^+/K^+-ATPase activity or inflammatory reaction. Alkaloids are closely related to the inhibition of inflammatory response and the improvement of antioxidant system. This paper aims to provide reference for further research and development of Chinese herbal medicine against alcoholic gastric injury.
作者
王雪雪
尹爱武
陶柱萍
厉颖
李灿委
范孟然
刘卫红
高鹏飞
WANG Xue-xue;YIN Ai-wu;TAO Zhu-ping;LI Ying;LI Can-wei;FAN Meng-ran;LIU Wei-hong;GAO Peng-fei(College of Pharmacy and Chemistry,Dali University,Dali 671000,China;Xiangtan Medicine and Health Vocational College,Xiangtan 411104,China;College of Public Health,Dali University,Dali 671000,China;Department of Agriculture and Biological Science,Dali University,Dali 671000,China;National Joint Engineering Research Center for Development of Medicinal Special Insects,Dali 671000,China;Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D,Dali University,Dali 671000,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2020年第20期4836-4845,共10页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(81260676
81960712)
云南省教育厅科学研究基金重点项目(2013Z154)
云南省地方本科高校(部分)基础研究联合专项项目(2018FH001-097)
云南省2019年中药饮片产业发展专项(2019-YG-067)。
关键词
中草药
酒精性胃损伤
活性成分
作用机制
Chinese herbal medicine
alcoholic gastric injury
active component
mechanism
