摘要
目的探讨异型淋巴细胞、EB病毒⁃DNA(EBV⁃DNA)和EBV抗CA⁃IgM(VCA⁃IgM)阳性率对传染性单核细胞增多症(IM)的诊断价值。方法收集2018年9月至2019年4月在宜宾市第一人民医院就诊的128例IM病儿和80例健康对照者。测试异型淋巴细胞、VCA⁃IgM和EBV⁃DNA的阳性率,并比较这3个指标在IM诊断中的价值。结果EB感染组异型淋巴细胞、VCA⁃IgM和EBV⁃DNA阳性率(61.72%、70.31%、95.31%)明显高于健康对照组,差异有统计学意义(P<0.001);EBV⁃DNA诊断IM的灵敏度(95.31%)和阴性预测值(92.94%)高于异型淋巴细胞(61.72%、62.02%)和VCA⁃IgM(70.31%、66.96%),差异有统计学意义(P<0.05),而后二者差异无统计学意义(P>0.05);三者诊断IM的特异度和阳性预测值差异无统计学意义(P>0.05)。三者联合检测诊断IM的灵敏度为96.88%,特异度为96.25%。结论EBV⁃DNA阳性率对IM的诊断效能高于其他两项检测指标,但异型淋巴细胞(大于10%)诊断IM的特异度达到100%。若三者联合检测,其对于IM的早期诊断价值将进一步提升。
Objective To investigate the diagnostic values of atypical lymphocytes,Epstein⁃Barr Virus DNA(EBV⁃DNA)and Ep⁃stein⁃Barr Virus Viral Capsid Antigen Antibody(VCA⁃IgM)positive rates in children with infectious mononucleosis(IM).Meth⁃ods The 128 patients with IM and 80 healthy controls were enrolled in The First People’s Hospital of Yibin from September 2018 to April 2019.The positive rates of atypical lymphocytes,VCA⁃IgM and EBV⁃DNA were tested,and the diagnostic values of these three indicators in IM were compared.Results The positive rates of atypical lymphocytes,VCA⁃IgM and EBV⁃DNA in EB⁃in⁃fected group(61.72%,70.31%,95.31%)were significantly higher than those in healthy control group,and the difference was statis⁃tically significant(P<0.001).The sensitivity and negative predictive value of EBV⁃DNA in the diagnosis of IM(95.31%,92.94%)were significantly higher than those of atypical lymphocytes(61.72%,62.02%)and VCA⁃IgM(70.31%,66.96%),and the difference was statistically significant(P<0.05).There was no significant difference between the latter two groups(P>0.05).There were no significant differences in the specificity and positive predictive value of IM between the three(P>0.05).The sensitivity of the com⁃bined detection of the three indicators to diagnose IM was 96.88%,and the specificity wa 96.25%.Conclusions The diagnostic ef⁃ficacy of EBV⁃DNA positive rate for IM is significantly higher than that of the other two indicators,but the specificity of atypical lymphocytes for the diagnosis of IM(greater than 10%)is 100%.If the three indicators are combined,their value in the early diag⁃nosis of IM will be further improved.
作者
张立营
陈朴
彭宇生
王鹏
ZHANG Liying;CHEN Pu;PENG Yusheng;WANG Peng(Department of Clinical Laboratory,The First People’s Hospital of Yibin,Yibin,Sichuan 644000,China)
出处
《安徽医药》
CAS
2020年第12期2502-2504,共3页
Anhui Medical and Pharmaceutical Journal
