摘要
目的研究硫酸羟氯喹口服联合康复新液、曲安奈德混合液含漱对糜烂型口腔扁平苔癣(OLP)病人血清差异蛋白、白细胞介素⁃12(IL⁃12)、白细胞介素⁃17(IL⁃17)的影响。方法选取2018年1月至2019年6月于河北北方学院附属第一医院口腔科门诊就诊的糜烂型OLP病人100例,依照随机数字表法分为试验组(n=50)与对照组(n=50)。对照组给予硫酸羟氯喹口服治疗(200 mg,2次/天)。试验组给予硫酸羟氯喹口服联合康复新液、曲安奈德混合液含漱治疗,康复新液、曲安奈德(1∶1)混合液10 mL含漱5 min吐掉,3次/天。均连续治疗4周。观察两组治疗前后糜烂面积、疼痛程度,血清人抗凝血酶⁃Ⅲ(AT⁃Ⅲ)、免疫球蛋白M(IgM)、锌α2糖蛋白(ZAG)等差异蛋白水平,血清IL⁃12、IL⁃17等炎性因子水平,不良反应。结果治疗后,试验组糜烂面积、疼痛视觉模拟评分法(VAS)评分,血清AT⁃Ⅲ、IgM、ZAG、IL⁃12、IL⁃17水平分别为(5.97±0.72)mm^2、(0.72±0.09)分、(131.76±14.29)μg/L、(1352.09±141.44)μg/L、(41.65±4.34)mg/L、(11.54±1.28)ng/L、(28.76±3.29)ng/L,均小于对照组[(6.53±0.77)mm^2、(0.80±0.10)分、(140.87±15.43)μg/L、(1458.57±153.65)μg/L、(44.37±4.63)mg/L、(12.37±1.36)ng/L、(31.04±3.33)ng/L](P<0.05)。试验组总有效率(94.00%)大于对照组(76.00%)(P<0.05)。试验组不良反应发生率(4.00%)与对照组不良反应发生率(8.00%)差异无统计学意义(P>0.05)。结论硫酸羟氯喹口服联合康复新液、曲安奈德混合液含漱治疗糜烂型OLP,可抑制机体免疫炎症反应,纠正差异蛋白及炎性因子异常改变,改善病人临床症状,缓解疼痛,抑制OLP恶性进程,安全可靠。
Objective To study the effects of oral Hydroxychloroquine sulfate combined with received gargle treatment with Kang⁃fuxin liquid and Triamcinolone mixture on serum Differential proteins,Interleukin 12(IL⁃12)and Interleukin 17(IL⁃17)in pa⁃tients with erosive oral lichen planus(OLP).Methods A total of 100 erosive OLP patients in Department of Stomatology,First Af⁃filiated Hospital of Hebei North University were selected from January 2018 to June 2019 and assigned into experimental group(n=50)and control group(n=50)according to random number table method.The control group was treated with hydroxychloroquine sulfate,while the experimental group with oral hydrochloroquine sulfate combined with received gargle treatment Kangfuxin liquid and triamcinolone,Rehab new solution,triamcinolone acetonide(1∶1)mixture 10 mL gargle 5 min vomit,3 times per day.All were treated continuously for 4 weeks.The erosion area and pain degree,the levels of serum Human AntithrombinⅢ(AT⁃Ⅲ),Immuno⁃globulin M(IgM),Zincα2 glycoprotein(ZAG)and other Differential proteins,serum IL⁃12,IL⁃17 and other inflammatory factors,and adverse reactions of the two groups before and after treatment were observed.Results After treatment,erosion area,VAS score,Serum AT⁃Ⅲ,IgM,ZAG,IL⁃12 and IL⁃17 levels AT⁃Ⅲ,IgM,ZAG,IL⁃12,IL⁃17 in experimental group were(5.97±0.72)mm^2,(0.72±0.09)score,(131.76±14.29)μg/L,(1352.09±141.44)μg/L,(41.65±4.34)mg/L,(11.54±1.28)ng/L,and(28.76±3.29)ng/L,respectively,which were lower than those in control group[(6.53±0.77)mm^2,(0.80±0.10)score,(140.87±15.43)μg/L,(1458.57±153.65)μg/L,(44.37±4.63)mg/L,(12.37±1.36)ng/L,and(31.04±3.33)ng/L,respectively](P<0.05).The total effec⁃tive rate of the experimental group(94.00%)was higher than that of the control group(76.00%)(P<0.05).The incidence of ad⁃verse reactions in experimental group and control group was 4.00%and 8.00%,respectively,there was no statistical difference(P>0.05).Conclusion Oral hydroxychloroquine sulfate with Kangfuxin liquid and triamcinolone mixture for gargle treatment of OLP caused by corrosion can inhibit the immune inflammatory response of the body,correct abnormal changes of differential proteins and inflammatory factors,improve the clinical symptoms of patients,relieve pain,and inhibit the malignant process of OLP,which is safe and reliable.
作者
王蕊
王芹
杜文斌
张慧
马赛
胥爱文
汪佳
安峰
WANG Rui;WANG Qin;DU Wenbin;ZHANG Hui;MA Sai;XU Aiwen;WANG Jia;AN Feng(Department of Stomatology,First Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei 075000,China;Department of Stomatology,Second Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei 075100,China)
出处
《安徽医药》
CAS
2020年第12期2523-2527,共5页
Anhui Medical and Pharmaceutical Journal
基金
张家口市科学技术和地震局项目(1821059D)。
