摘要
目的探讨妊娠期高血压(HDCP)产妇血清半乳糖凝集素1(Galectin-1)、半乳糖凝集素3(Galectin-3)表达与胎盘早剥的关系。方法抽取2018年5月至2019年5月郑州大学附属洛阳中心医院产科收治的149例HDCP孕妇为病例组,另选同期在医院规律产检的正常孕妇149例为对照组,比较病例组与对照组血清Galectin-1、Galectin-3水平。根据149例HDCP孕妇是否发生胎盘早剥分为非胎盘早剥组(119例)与胎盘早剥组(30例),比较非胎盘早剥组与胎盘早剥组血清Galectin-1、Galectin-3水平,采用spearman相关分析妊娠期高血压疾病孕妇血清Galectin-1、Galectin-3水平与胎盘早剥的相关性,采用多因素Logistic回归分析妊娠期高血压疾病孕妇胎盘早剥的影响因素。结果病例组血清Galectin-1、Galectin-3水平高于对照组(P<0.05);胎盘早剥组血清Galectin-1、Galectin-3水平高于非胎盘早剥组(P<0.05);妊娠期高血压疾病孕妇血清Galectin-1、Galectin-3水平与胎盘早剥呈正相关(P<0.05);血清Galectin-1、Galectin-3高水平是妊娠期高血压疾病孕妇胎盘早剥的危险因素(P<0.05)。结论Galectin-1、Galectin-3在妊娠期高血压疾病孕妇外周血中呈高水平,血清Galectin-1、Galectin-3高水平有助于预测妊娠期高血压疾病孕妇胎盘早剥的发生。
Objective To investigate the relationship between the expression of Galectin-1,Galectin-3 and placental abruption in hypertensive disorder complicating pregnancy(HDCP).Methods A total of 149 HDCP women(case group)and 149 healthy pregnant women(control group)in Luoyang Central Hospital Affiliated to Zhengzhou University from May 2018 to May 2019 were enrolled.Case group was further divided into two groups according to the absence or presence of placental abruption,non-placental abruption group(n=119)and placental abruption group(n=30).Comparison of Galectin-1 and Galectin-3 expression levels was carried out within groups and subgroups.Spearman correlation was used to analyze the correlation between serum Galectin-1 and Galectin-3 levels and placental abruption in HDCP women,and multivariate Logistic regression was used to analyze the influencing factors of placental abruption in HDCP women.Results The serum levels of galectin-1 and galectin-3 in case group were significantly higher than those in control group(P<0.05).The serum levels of Galectin-1 and Galectin-3 in placental abruption group were significantly higher than those in non-placental abruption group(P<0.05).Serum levels of galectin-1 and galectin-3 in HDCP women were positively correlated with placental abruption(P<0.05).High serum levels of Galectin-1 and Galectin-3 were risk factors for placental abruption in HDCP women(P<0.05).Conclusions Galectin-1 and Galectin-3 show high levels in peripheral blood of HDCP women,and high levels of Galectin-1 and Galectin-3 in serum can be used to predict placental abruption in HDCP women.
作者
郑懿
Zheng Yi(Department of Obstetrics,Luoyang Central Hospital Affiliated to Zhengzhou University,Luoyang 471000,China)
出处
《中国实用医刊》
2020年第20期62-65,共4页
Chinese Journal of Practical Medicine
