摘要
目的分析蛹虫草在治疗慢性肾脏病(CKD)方面的分子机制。方法 98例CKD患者,将所有患者随机分为蛹虫草组(服用蛹虫草100 mg/d,为期3个月)和对照组(每日服用等量淀粉作安慰剂,为期3个月),每组49例。比较两组患者治疗前后肾功能指标[尿蛋白、尿素氮(BUN)、肌酐(Cr)]、血脂指标[血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]、氧化还原特征指标[血清胱抑素C(Cys-C)、髓过氧化物酶(MPO)、丙二醛(MDA)、一氧化氮(NO)、超氧化物歧化酶(SOD)]水平。结果治疗3个月后,蛹虫草组尿蛋白、BUN、Cr水平分别为(1.36±0.45)g/24 h、(8.84±2.36)mmol/L、(149.1±25.5)μmol/L,均低于对照组的(2.65±0.73)g/24 h、(9.72±2.38)mmol/L、(204.0±31.8)μmol/L,差异均具有统计学意义(P<0.05)。治疗3个月后,蛹虫草组TC、TG、LDL-C分别为(4.9±0.5)、(2.0±0.6)、(1.7±0.5)mmol/L,均低于对照组的(5.9±0.7)、(2.4±0.9)、(2.2±0.6)mmol/L, HDL-C水平(1.9±0.5)mmol/L高于对照组的(1.7±0.5)mmol/L,差异均具有统计学意义(P<0.05)。蛹虫草组Cys-C、MPO、MDA水平分别为(0.8±0.2)mg/L、(14.5±3.4)mg/L、(5.4±1.9)mmol/L,均低于对照组的(1.0±0.3)mg/L、(23.3±4.3)mg/L、(8.1±2.5)mmol/L, NO(6.8±2.5)μmol/L、SOD(698.4±145.6)U/L均高于对照组的(5.8±2.1)μmol/L、(521.4±123.8)U/L,差异均具有统计学意义(P<0.05)。结论蛹虫草可通过影响脂质和氧化还原信号传导途径对CKD起保护作用,为目前评估虫草素对抑制CKD的临床试验提供了进一步的支持。
Objective To analyze the molecular mechanism of Cordyceps militaris in the treatment of chronic kidney disease(CKD). Methods A total of 98 CKD patients were randomly divided into Cordyceps militaris group(taking Cordyceps militaris 100 mg/d for 3 months) and control group(taking the same amount of starch as a placebo daily for 3 months), with 49 cases in each group. The renal function [urinary protein, blood urea nitrogen(BUN), creatinine(Cr)], blood lipids [serum total cholesterol(TC), triglycerides(TG), low density lipoprotein cholesterol(LDL-C), high-density lipoprotein cholesterol(HDL-C)], redox characteristics [serum cystatin C(Cys-C), myeloperoxidase(MPO), malondialdehyde(MDA), nitric oxide(NO), superoxide dismutase(SOD)] levels before and after treatment were compared between the two groups. Results 3 months after treatment, the urine protein, BUN, Cr levels of Cordyceps militaris group were(1.36±0.45) g/24 h,(8.84±2.36) mmol/L and(149.1±25.5) μmol/L, which were all lower than(2.65±0.73) g/24 h,(9.72±2.38) mmol/L and(204.0± 31.8) μmol/L of the control group, and the difference was statistically significant(P<0.05). 3 months after treatment, TC, TG and LDL-C of Cordyceps militaris group were(4.9±0.5),(2.0±0.6) and(1.7±0.5) mmol/L, which were all lower than(5.9±0.7),(2.4±0.9) and(2.2±0.6) mmol/L of the control group, and HDL-C(1.9± 0.5) mmol/L was higher than(1.7±0.5) mmol/L of the control group, and the difference was statistically significant(P<0.05). Cys-C(0.8±0.2) mg/L, MPO(14.5±3.4) mg/L and MDA(5.4±1.9) mmol/L of Cordyceps militaris group were lower than(1.0±0.3) mg/L,(23.3±4.3) mg/L and(8.1±2.5) mmol/L of the control group, and NO(6.8±2.5) μmol/L and SOD(698.4±145.6) U/L were higher than(5.8±2.1) μmol/L and(521.4±123.8) U/L of the control group, and the difference was statistically significant(P<0.05). Conclusion Cordyceps militaris can protect CKD by affecting lipid and redox signal transduction pathway. It provides further support for the evaluation of cordycepin to inhibit CKD clinical trials.
作者
孙婷丽
SUN Ting-li(Department of Nephrology,Daqing Oilfield General Hospital,Daqing 163001,China)
出处
《中国实用医药》
2020年第32期4-6,共3页
China Practical Medicine
基金
大庆市指导性科技计划项目(项目编号:zdy-2019-73)。
关键词
蛹虫草
慢性肾脏病
氧化还原
Cordyceps militaris
Chronic kidney disease
Redox
