摘要
目的分析透明质酸钠联合利多卡因行膀胱灌注治疗女性膀胱过度活动症(OAB)的效果。方法选取2017年1月至2019年1月本院收治的女性OAB患者110例,采用数字随机分组方法,将其分为观察组和对照组,观察组应用透明质酸钠联合利多卡因行膀胱灌注治疗,每周1次,连续1年,对照组给予索利那新对症治疗,比较两组患者治疗后的膀胱过度活动症症状评分(OABSS)及尿流动力学指标变化情况。结果观察组治疗2个月后的轻度患者比例及治疗6个月后的中度患者均较对照组多,差异具有统计学意义(P<0.05),且相较于对照组,观察组重度转为轻度或中度比例明显升高(P<0.05),而对照组在治疗12个月后又转为重度患者。观察组在治疗2、6、12个月后的OABSS与治疗前相比均显著降低,而对照组治疗2、6个月后与治疗前相比显著降低(P<0.05),但治疗12个月后与治疗前比较,差异无统计学意义(P>0.05)。观察组用药2、6、12个月后首次排尿感觉容量(FDV)、最大膀胱压容量(MCBC)、最大尿流率(Qmax)较用药前升高,差异有统计学意义(P<0.05)。对照组用药2、6、12个月后的尿动力学指标与用药前比较,差异无统计学意义(P>0.05)。结论透明质酸钠联合利多卡因治疗OAB能够明显提高治疗效果,无明显不良反应,值得推广应用。
Objective To analyze the effect of sodium hyaluronate combined with lidocaine in the treatment of female overactive bladder(0AB).Methods From January 2017 to January 2019,a total of 110 female with severe 0AB patients were enrolled in the outpatient department and hospitalized in our hospital.The patients were divided into observation group and placebo control group by digital randomization.The observation group was treated with sodium hyaluronate combined with lidocaine for perfusion.One time a week,one year in a row,the control group was given a new symptomatic treatment of Solifenacin,and the changes of OABSS symptom scores and urodynamics after treatment were compared between the two groups.Results The proportion of mild patients in the observation group and the proportion of moderate patients in the second month after treatment were significantly different from those in the control group(P<0.05),and the observation group was severely changed compared with the control group.The mild or moderate proportion was significantly increased(P<0.05),while the control group was converted to severe patients 12 months after treatment.The OABSS scores of the observation group were significantly lower than those before treatment in the 2,6 and 12 months after treatment,while the control group was significantly lower than the pre-treatment 2 and 6 months after treatment(P<0.05),but 12 months after treatment.There was no significant difference compared to the treatment before treatment(P>0.05).The difference of OABSS scores between two groups at each time point after treatment was statistically significant(P<0.05).There were significant differences in the urodynamic parameters FDV,MCC and Q between the observation group in 2,6 and 12 months after treatment(P<0.01).There was no significant difference in the urodynamic parameters in the control group at the times of 2,6 and 12 months after administration(P>0.05).Conclusions The application of sodium hyaluronate combined with lidocaine in the treatment of overactive bladder can significantly improve the treatment effect,has no obvious adverse reactions,and it is worthy of popularization and application.
作者
潘良明
沈菲菲
马晓英
盛依青
沈建良
Pan Liangming;Shen Feifei;Ma Xiaoying;Sheng Yiqing;Shen Jianliang(Department of Urology,Shanghai Jinshan District Tinglin Hospital,Shanghai 201505,China;Department of Rehabiliation,Shanghai Jinshan District Tinglin Hospial,Shanghai 201505,China)
出处
《国际泌尿系统杂志》
2020年第6期1051-1054,共4页
International Journal of Urology and Nephrology
