摘要
D-二聚体是一种可溶的纤维蛋白降解产物,由纤维蛋白溶解系统对血栓的有序分解产生。D-二聚体作为凝血和纤溶激活的重要标志,其检测方法多样。临床上,D-二聚体主要作为凝血功能障碍性疾病和血栓性疾病的诊疗检测指标。近年来,随着研究的深入,D-二聚体在其他疾病和生理状态(如心房颤动、心搏骤停、妊娠状态)中也有升高,D-二聚体可能在这些疾病的诊断、评估治疗效果及预后中具有一定的意义。但由于D-二聚体水平受到年龄、种族差异的影响,其临床应用受到限制,故未来应用仍需要进一步研究。
D-dimer is a soluble fibrin degradation product,which is produced by the orderly decomposition of thrombus by the fibrinolytic system.D-dimer can be used as an important indicator of coagulation and fibrinolysis activation,and there are many detection methods.In clinical practice,D-dimer is mainly used as an index for the diagnosis and treatment of coagulopathy and thrombotic diseases.In recent years,with the deepening of the research,it is reported that the level of D-dimer has also increased in other diseases and physiological states,such as atrial fibrillation,cardiac arrest,and pregnancy status.D-dimer may have certain significance in the diagnosis,evaluation of treatment effects and prognosis of these diseases.However,because the level of D-dimer is also affected by age and ethnic differences,the clinical application of D-dimer is still limited,and further research is needed.
作者
雷孝波
王秀杰
LEI Xiaobo;WANG Xiujie(Department of Emergency Medicine,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,China)
出处
《医学综述》
2020年第22期4521-4527,共7页
Medical Recapitulate
关键词
D-二聚体
血液学检验
血栓形成
弥散性血管内凝血
心脑血管疾病
恶性肿瘤
获得性免疫缺陷综合征
妊娠
D-dimer
Hematological examination
Thrombosis
Disseminated intravascular coagulation
Cardio-cerebrovascular disease
Malignant tumor
Acquired immune deficiency syndrome
Pregnancy
