摘要
目的观察使用帕罗西汀治疗产后抑郁症的疗效及其对神经内分泌功能的影响。方法选取湖北省十堰市妇幼保健院2018年3月至2019年3月收治的产后抑郁症患者112例,随机分为观察组和对照组,各56例。观察组给予帕罗西汀治疗,对照组给予马普替林治疗,两组患者均治疗6周。结果观察组治疗总有效率为91.07%,高于对照组的76.79%(P <0.05);观察组患者治疗后的雌二醇(E2)、催乳激素(PRL)、孕酮(P)、血清皮质醇、促肾上腺皮质激素(ACTH)、5-羟色胺(5-HT)含量变化均优于对照组(P <0.05),汉密尔顿抑郁(HAMD)量表、爱丁堡产后抑郁(EPDS)量表、匹茨堡睡眠质量指数(PSQI)量表评分变化优于对照组(P <0.05);观察组不良反应发生率为5.36%,低于对照组的12.50%,但差异无统计学意义(P> 0.05)。结论帕罗西汀治疗产后抑郁症疗效确切,能通过调节女性性激素水平,改善神经内分泌功能,提高睡眠质量,从而减轻产后抑郁症状,治疗安全性较好。
Objective To observe the efficacy of paroxetine in the treatment of postpartum depression and its effect on neuroendocrine function.Methods Totally 112 patients with postpartum depression admitted to our hospital from March 2018 to March 2019 were selected and randomly divided into the observation group and the control group,56 cases in each group.The patients in the observation group were treated with paroxetine,while the patients in the control group were treated with maprotiline.Both groups were continuously treated for 6 weeks.Results The total effective rate of the observation group was 91.07%,which was higher than 76.79%of the control group(P<0.05).After treatment,the changes in contents of estradiol(E2),prolactin(PRL),progesterone(P),serum cortisol,adrenocorticotropic hormone(ACTH)and 5-hydroxytryptamine(5-HT)in the observation group were better than those in the control group(P<0.05).After treatment,the changes in scores of Hamilton Depression Scale(HAMD),the Edinburgh Postpartum Depression Scale(EPDS)and the Pittsburgh Sleep Quality Index(PSQI)in the observation group were better than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the observation group and the control group(5.36%vs.12.50%,P>0.05).Conclusion Paroxetine is effective in the treatment of postpartum depression,it can further reduce the symptoms of postpartum depression with good safety by regulating the levels of female sex hormones,improving neuroendocrine function and sleep quality.
作者
张玉
李丽
刘红艳
ZHANG Yu;LI Li;LIU Hongyan(Department of Obsteries,Shiyanr Matermal and Cald HealthaHopta,Shtyn,Hubei,CNhina 442099;Dpurtimemnt of Oistraris,Tatie Hospital,Shiyan,Hubei,China 442099)
出处
《中国药业》
CAS
2020年第23期89-91,共3页
China Pharmaceuticals
基金
湖北省自然科学基金[2017CFB865]。
关键词
产后抑郁症
帕罗西汀
临床疗效
神经内分泌功能
postpartum depression
paroxetine
clinical efficacy
neuroendocrine function
