摘要
类风湿关节炎患者存在氧化型低密度脂蛋白水平的升高。氧化型低密度脂蛋白与其受体结合,通过相关通路促进类风湿关节炎的发生发展及心血管疾病风险,检测氧化型低密度脂蛋白含量对判断类风湿关节炎患者病情及早期发现其心血管风险有一定的临床价值,但是氧化型低密度脂蛋白水平所受影响因素多,它跟高密度脂蛋白和低密度脂蛋白比值不受药物或炎症等诸多因素的影响,未来需要进一步研究脂质比在评估类风湿关节炎患者心血管风险中的作用。
Patients with rheumatoid arthritis have elevated levels of oxidized low-density lipoprotein(LDL),and oxidized LDL promotes the development of rheumatoid arthritis in many aspects through binding to its receptor,which can increase the risk of cardiovascular disease.The detection of oxidized LDL has certain clinical value for the estimation of disease state and the early detection of its cardiovascular risk in rheumatoid arthritis.However,the level of oxidized LDL is affected by many factors,and its ratio with high density lipoprotein and LDL is not affected by factors such as drugs or inflammation.In the future,the role of its lipid ratio in the assessment of cardiovascular risk in patients with rheumatoid arthritis needs to be further studied.
作者
艾比班·麦麦提牙克夫(综述)
武丽君(审校)
Aibiban Maimaitiyakefu;WU Li-jun(Xinjiang Medical University Urumqi 830011,Xinjiang,CHINA;Department of Rheumatology and Immunology,People's Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830001,Xinjiang,CHINA)
出处
《海南医学》
CAS
2020年第22期2964-2967,共4页
Hainan Medical Journal
基金
国家卫生健康委科教司技术推广扶贫项目(编号:2019JSTG09)。
关键词
类风湿关节炎
氧化型低密度脂蛋白
慢性炎症
低密度脂蛋白
脂质比
心血管疾病
Rheumatoid arthritis
Oxidized low-density lipoprotein
Chronic inflammation
Low density lipoprotein(LDL)
Lipoprotein ratio
Cardiovascular disease
