摘要
目的观察补肺活血汤对肺脾两虚,痰瘀互结型非小细胞肺癌患者术后快速康复的促进作用。方法行手术治疗的肺脾两虚,痰瘀互结型非小细胞肺癌107例患者随机分为治疗组和对照组,2组行手术治疗,治疗组加服补肺活血汤,每日1剂,术前1天开始,术后5 d为止。治疗5 d后,比较2组临床疗效、中医证候积分改善情况、术后炎症指标、并发症和康复情况。结果2组患者术后中医证候积分均较术前明显改善(P<0.05~0.01),治疗组改善情况优于对照组(P<0.05),治疗组临床总有效率高于对照组(P<0.05);治疗组C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)在术后第3天和第5天均低于对照组(P<0.05);治疗组术后胸腔引流量、术后卧床时间和住院天数均少于对照组(P<0.05);治疗组术后第5天的动脉血氧分压(PaO2)高于对照组(P<0.05)。结论补肺活血汤可以减轻非小细胞肺癌患者术后的炎症反应,促进患者快速恢复,符合加速康复外科的理念,值得进一步推广应用。
OBJECTIVE To observe the effect of Bufei Huoxue Decoction on promoting the rapid postoperative recovery of non-small cell lung cancer(NSCLC)patients with deficiency of lung and spleen along with phlegm and blood-stasis.METHODS 107 patients with lung and spleen deficiency along with phlegm and blood stasis type non-small cell lung cancer were randomly divided into the treatment group and the control group,and both were given surgery therapy.The treatment group has been given Bufei Huoxue Decoction,one dose a day,1 day before surgery and 5 days after surgery.After 5 days'treatment,the clinical efficacy,traditional Chinese medicine(TCM)syndrome scores,postoperative inflammation indicators,conditions of complications and rehabilitation were compared between the two groups.RESULTS The scores of TCM syndromes in the two groups were significantly improved after surgery(P<0.05,P<0.01)and the treatment group was better(P<0.05).The total clinical effective rate of the treatment group was higher than that of the control group(P<0.05).C-reactive protein(CRP),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α)in the treatment group were lower than those in the control group on the 3rd and 5th day after surgery(P<0.05).Postoperative thoracic drainage,postoperative bedtime and hospital days in the treatment group were less than those in the control group(P<0.05).The partial arterial oxygen pressure(PaO2)on the 5th day after surgery in the treatment group was higher than that of the control group(P<0.05).CONCLUSION Bufei Huoxue Decoction can reduce the postoperative inflammatory response of patients with non-small cell lung cancer and promote rapid recovery,in line with the concept of accelerated rehabilitation surgery and is worthy of further promotion and application.
作者
傅兆庆
张云杰
史进
FU Zhao-qing;ZHANG Yun-jie;SHI Jin(The Affiliated Provincial Hospital of Shandong University, Jinan, 250021, China;The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250014, China)
出处
《南京中医药大学学报》
CAS
CSCD
北大核心
2020年第6期804-808,共5页
Journal of Nanjing University of Traditional Chinese Medicine
基金
山东省中医药科技发展计划重点项目(2009Z003)。
关键词
非小细胞肺癌
快速康复外科
中西医结合
补肺活血汤
non-small cell lung cancer
rapid rehabilitation surgery
integrated Chinese and western medicine
Bufei Huoxue Decoction
