摘要
目的分析与研究难治性精神分裂症患者采用利培酮与奥氮平两种药物治疗的效果与安全性对比。方法于2018年1月—2020年1月选取该院收治的80例难治性精神分裂症患者,按照双盲法分为两组,对照组40例患者予以利培酮治疗,观察组40例患者予以奥氮平治疗,并对两组患者的治疗总有效率、PANSS评分以及不良反应发生率进行对比。结果观察组总有效率90.00%,与对照组的67.50%相比较高,差异有统计学意义(P<0.05);治疗前两组患者PANSS评分比较,差异无统计学意义(P>0.05);治疗后1、2、3个月PANSS评分均低于治疗前,且观察组治疗后1、2、3个月阴性症状与总分与对照组比较,差异有统计学意义(P<0.05);观察组不良反应发生率2.50%(0例血糖升高、1例体质量增加、0例肌强直),低于对照组的20.00%(2例血糖升高、3例体质量增加、3例肌强直),差异有统计学意义(P<0.05)。结论与利培酮相比,奥氮平对难治性精神分裂症患者的治疗效果较好,且不良反应较少,可使患者的临床症状显著改善。
Objective To analyze and study the efficacy and safety of risperidone and olanzapine in patients with refractory schizophrenia.Methods From January 2018 to January 2020,80 patients with refractory schizophrenia admitted to the hospital were selected and divided into 2 groups according to the double-blind method.40 patients in the control group were treated with risperidone,40 patients in the observation group were treated with olanzapine,and the total effective rate,PANSS score and incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 90.00%,which was higher than 67.50%of the control group,and the difference was statistically significant(P<0.05);before treatment,the difference in PANSS scores between the two groups of patients was not statistically significant(P>0.05);The PANSS scores were lower than those before treatment at 1,2,and 3 months,and the negative symptoms and total scores of the observation group were compared with those of the control group at 1,2,and 3 months after treatment,and the difference was statistically significant(P<0.05);The incidence of adverse reactions in the group was 2.50%(0 cases of increased blood sugar,1 case of weight gain,0 cases of muscle rigidity),which was lower than 20.00%of the control group(2 cases of blood glucose increase,3 cases of weight gain,3 cases of muscle rigidity).The difference was statistically significant(P<0.05).Conclusion Compared with risperidone,olanzapine has a better therapeutic effect on patients with refractory schizophrenia,and has fewer adverse reactions,which can significantly improve the clinical symptoms of patients.
作者
魏飞飞
WEI Fei-fei(Department of Psychiatry,Section Two,Qinglongshan Psychiatric Hospital,Nanjing,Jiangsu Province,211123 China)
出处
《系统医学》
2020年第22期43-45,共3页
Systems Medicine
关键词
难治性精神分裂症
利培酮
奥氮平
治疗效果
不良反应
Refractory schizophrenia
Risperidone
Olanzapine
Treatment effect
Adverse reactions
