摘要
目的:观察多巴胺(DA)联合呋塞米(BAN)对利尿剂抵抗性心力衰竭(CHF)患者超声心动图指标及肾功能的影响。方法:将于本院就诊的180例利尿剂抵抗性CHF患者随机分为对照组(n=90,单用BAN治疗)和观察组(n=90,在对照组基础上联用DA),比较两组治疗前和治疗12 d后超声心动图指标[左室射血分数(LVEF)、左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD)]、肾功能[24 h尿量、血肌酐(CREA)、尿水通道蛋白2(AQP2)]以及治疗期间不良反应发生情况。结果:治疗12 d后,两组LVEF、24 h尿量均较治疗前显著升高,且观察组明显高于对照组(P<0.05);两组LVESD、LVEDD、CREA、AQP2均显著低于治疗前,且观察组显著低于对照组(P<0.05);两组各项药物不良反应情况差异不明显(P>0.05)。结论:DA联合BAN对利尿剂抵抗性心力衰竭患者超声心动图指标及肾功能均有显著改善作用,有利于预后恢复。
Objective:To observe the effect of dopamine(DA)combined with furosemide(BAN)on echocardiography and renal function in patients with diuretic resistant heart failure(CHF).Methods:180 patients with diuretic resistant CHF in our hospital were randomly divided into control group(n=90,treated with ban alone)and observation group(n=90,combined with DA on the basis of control group).Echocardiographic indexes[left ventricular ejection fraction(LVEF),left ventricular end systolic diameter(LVESD),left ventricular end diastolic diameter(LVEDD)]and renal function[24 h urine volume,serum creatinine(crea),urinary aquaporin 2(AQP2)]and the incidence of adverse reactions during the treatment.Results:After 12 days of treatment,LVEF and 24 h urine volume of the two groups were significantly higher than those before treatment,and the observation group was significantly higher than the control group(P<0.05);LVESD,LVEDD,CREA,AQP2 in the two groups were significantly lower than those before treatment,and the observation group was significantly lower than the control group(P<0.05);there was no significant difference in adverse drug reactions between the two groups(P>0.05).Conclusion:DA combined with BAN can significantly improve echocardiographic indexes and renal function in patients with diuretic resistant heart failure,which is conducive to the recovery of prognosis.
作者
王璐芳
常超
赵亚莉
WANG Lufang;CHANG Chao;ZHAO Yali(Department of Cardiovascular Medicine,The First People's Hospital of Luoyang,Luoyang Henan 471000,China)
出处
《药品评价》
CAS
2020年第17期53-55,共3页
Drug Evaluation
