摘要
目的探讨慢性乙型肝炎患者免疫球蛋白(Ig)检测的临床意义。方法选择2018年1月—2020年3月单县东大医院收治的90例慢性乙型肝炎患者作为慢性乙型肝炎组,根据病情严重程度不同分为轻度组(31例)、中度组(39例)和重度组(20例);另选择90例健康体检者作为健康对照组。采集所有受检者空腹静脉血,采用免疫散射比浊法测定IgA、IgG、IgM水平,分析并比较慢性乙型肝炎组和健康对照组的血清Ig水平以及不同病情严重程度慢性乙型肝炎患者的血清Ig水平;采用Spearman相关性分析法分析Ig与慢性乙型肝炎患者病情严重程度的相关性。结果慢性乙型肝炎组血清IgA、IgG、IgM水平均明显高于健康对照组〔IgA(g/L):4.03±1.21比2.65±0.83,IgG(g/L):14.56±3.08比11.37±2.54,IgM(g/L):2.94±0.90比1.93±0.64〕,差异均有统计学意义(均P<0.01);轻度组、中度组、重度组慢性乙型肝炎患者的血清IgA、IgG、IgM水平逐渐升高〔IgA(g/L):3.63±0.42、4.01±0.39、4.43±0.41,IgG(g/L):13.24±1.29、14.50±1.21、16.75±1.23,IgM(g/L):2.68±0.24、2.92±0.25、3.19±0.28〕,差异均有统计学意义(均P<0.01)。Spearman相关性分析结果显示,血清IgA、IgG、IgM水平与慢性乙型肝炎患者病情严重程度均呈正相关(r=0.760、0.798、0.727,P=0.002、0.007、0.003)。结论慢性乙型肝炎患者体内普遍出现Ig异常升高,随病情加重,Ig升高越明显,临床上可将Ig检验作为慢性乙型肝炎诊断及病情评估的辅助手段。
Objective To investigate the clinical significance of immunoglobulin(Ig)test in patients with chronic hepatitis B.Methods From January 2018 to March 2020,90 cases of patients with chronic hepatitis B admitted in Shanxian Dongda Hospital were selected as chronic hepatitis B group;according to the severity of disease,the patients were divided into mild group(31 cases),moderate group(39 cases)and severe group(20 cases);and other 90 healthy people were selected as healthy control group.The fasting venous blood of the two groups were collected,and the IgA,IgG and IgM levels were determined by immune scattering turbidimetric method.The serum Ig levels of chronic hepatitis B group and healthy control group,and the Ig levels among the patients with different severities of disease were analyzed and compared.Spearman correlation analysis was used to analyze the correlation between Ig and severity of chronic hepatitis B.Results Compared with the healthy control group,the serum IgA,IgG and IgM levels in chronic hepatitis B group were significantly higher[IgA(g/L):4.03±1.21 vs.2.65±0.83,IgG(g/L):14.56±3.08 vs.11.37±2.54,IgM(g/L):2.94±0.90 vs.1.93±0.64],with significant differences(all P<0.01).The levels of serum IgA,IgG and IgM in mild group,moderate group and severe group were increased gradually[IgA(g/L):3.63±0.42,4.01±0.39,4.43±0.41,IgG(g/L):13.24±1.29,14.50±1.21,16.75±1.23,IgM(g/L):2.68±0.24,2.92±0.25,3.19±0.28],with significant differences(all P<0.01).Spearman correlation analysis showed that serum IgA,IgG and IgM levels were positively correlated with the severity of chronic hepatitis B(r=0.760,0.798,0.727,P=0.002,0.007,0.003).Conclusions The abnormal increase of Ig in patients with chronic hepatitis B is common.With the aggravation of the disease,the more obvious the increase of Ig is.Ig detection can be used as an auxiliary means in the diagnosis and evaluation of chronic hepatitis B.
作者
郭杰
Guo Jie(Clinical Laboratory,Shanxian Dongda Hospital,Heze 274300,Shandong,China)
出处
《实用检验医师杂志》
2020年第4期207-209,共3页
Chinese Journal of Clinical Pathologist
关键词
慢性乙型肝炎
免疫球蛋白
临床医学检验
Chronic hepatitis B
Immunoglobulin
Clinical medical examination
