摘要
随着一氧化碳(carbonic oxide,CO)的保护和治疗作用被发现,越来越多的研究将外源CO应用于临床治疗。一氧化碳释放分子(carbon monoxide releasing molecule,CORM)能稳定释放CO,在多领域实验研究中展现了调节细胞增殖、抗凋亡、抗炎、抗氧化等功能,有效地保护了动物机体及重要器官,有良好的应用前景。本文主要从血管扩张、抗炎、抗缺血再灌注、抗肿瘤等方面总结了当前CORM在基础医学中的应用研究进展,旨在探究其应用于临床治疗的潜力。
With the discovery of protective and therapeutic effects of carbonic oxide(CO),more and more studies have applied exogenous CO in clinical treatment.Carbon monoxide releasing molecule(CORM)has a stable release of CO,and has demonstrated in many field experimental studies the functions of regulating cell proliferation,anti-apoptosis,anti-inflammatory and anti-oxidation,etc.and effectively protects the body and important organs of animals,showing a good application prospect.In this paper,the application of CORM in basic medicine was summarized from the aspects of vasodilation,anti-inflammatory,anti-ischemia-reperfusion and anti-tumor,so as to explore its potential in clinical treatment.
作者
吴剑华
李彦霖
王一川(综述)
陈娜
杨雪亮
刘小静(审校)
WU Jianhua;LI Yanlin;WANG Yichuan;CHEN Na;YANG Xueliang;LIU Xiaojing(Department of Infectious Diseases,First Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710010,China)
出处
《临床与病理杂志》
2020年第11期3010-3015,共6页
Journal of Clinical and Pathological Research
基金
国家重大科技基金项目(2017ZX10201201-001-004,2017ZX10201201-002-004,2017ZX10201201-004-003)。
关键词
一氧化碳释放分子
研究进展
炎症反应
缺血再灌注
carbon monoxide releasing molecule
research progress
inflammatory response
ischemia-reperfusion
