摘要
目的探讨平肝活血汤联合氨氯地平对高血压合并冠心病的疗效及对血浆ADM、ET-1变化的影响。方法将2018年5月—2019年5月收治的90例高血压合并冠心病患者随机分为对照组与研究组,每组45例。对照组采用氨氯地平治疗,研究组患者采用平肝活血汤联合氨氯地平,治疗2组均治疗4周。比较2组临床效果、血浆肾上腺髓质素(ADM)以及内皮素1(ET-1)变化及不良反应发生情况。结果与干预前比较,干预后2组ADM、ET-1显著降低(P<0.01);干预后与对照组比较,研究组总有效率显著较高(P<0.01),ADM、ET-1显著较低(P<0.01)。2组患者的不良反应发生率比较,差异无统计学意义(P>0.05)。结论平肝活血汤联合氨氯地平对高血压合并冠心病的临床疗效显著,其调节机制可能与下调血浆ADM、ET-1水平具有相关性。
Objective To explore the effect of Pinggan Huoxue decoction combined with amlodipine on hypertension combined with coronary heart disease and the changes of plasma ADM and ET-1.Methods 90 cases of hypertension complicated with coronary heart disease from May 2018 to May 2019 were randomly divided into the control group and the study group,with 45 cases in each group.The control group received amlodipine,and the study group received more with Pinggan Huoxue decoction.2 groups were treated for 4 weeks.The clinical effects,changes of plasma adrenomedullin(ADM)and endothelin-1(ET-1)and adverse reactions were compared between the two groups.Results Compared with the control group after intervention,the total effective rate in the study group was significantly higher(P<0.01),levels of ADM and ET-1 in the study group were significantly lower(P<0.01).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Pinggan Huoxue decoction combined with amlodipine has a significant clinical effect on hypertension complicated with coronary heart disease,and its regulatory mechanism may be related to the down-regulation of plasma ADM and ET-1 levels.
作者
吕艳芳
LYU Yanfang(Center for Preventive Treatment of Disease,the Fourth People’s Hospital of Shenyang,Liaoning Province,Shenyang 110032,China)
出处
《中国中医药现代远程教育》
2020年第22期116-117,120,共3页
Chinese Medicine Modern Distance Education of China
关键词
平肝活血汤
氨氯地平
高血压
冠心病
中西医结合疗法
ADM
ET-1
Pinggan Huoxue decoction
amlodipine
hypertension
coronary heart disease
therapy of integrate traditional Chinese and Western medicine
ADM
ET-1
