摘要
甲状腺癌是常见的内分泌肿瘤,发病率逐年上升。甲状腺癌的发生、发展过程与v-raf鼠类肉瘤滤过性病毒致癌基因同源体B1、端粒酶逆转录酶、P53等多种基因突变相关,了解甲状腺癌患者基因突变具体情况对于明确患者发病机制以及制定靶向治疗方案均具有重要意义。该文就甲状腺癌相关基因以及靶向治疗研究进展进行综述,以期为甲状腺癌发病机制以及治疗提供一定参考。
Thyroid carcinoma is a common type of endocrine tumors,and its incidence rate has been increasing year by year.The incidence and development of thyroid carcinoma are correlated with genetic mutations in v-raf murine sarcoma viral oncogene homolog B1,telomerase reverse transcriptase,P53 and other genes.Understanding the specific situation of genetic mutations in patients with thyroid carcinoma is of great significance for elucidating the pathogenesis and establishing targeted therapy.In this article,research progresses on thyroid carcinoma-related genes and targeted therapy were reviewed,aiming to provide certain reference for the pathogenesis and treatment of thyroid carcinoma.
作者
李响
马芙蓉
Li Xiang;Ma Furong(The Second Clinical Medical College of Lanzhou University,Lanzhou 730000,China)
出处
《新医学》
2020年第12期902-906,共5页
Journal of New Medicine
基金
甘肃省科技计划项目(18JR3RA312)。
关键词
甲状腺癌
基因
靶向治疗
Thyroid carcinoma
Gene
Targeted therapy
