摘要
目的观察虾青素对非酒精性脂肪肝(Nonalcoholic fatty liver disease,NAFLD)的治疗作用。方法采用高脂乳剂灌胃法建立非酒精性脂肪肝大鼠模型,观察肝脂、血脂、肝功能和肝组织病理形态改变。结果与正常对照组比较,模型组血脂(P<0.01)、肝脂(P<0.01)显著升高,病理切片可见干细胞肿胀、坏死,肝小叶结构模糊不清;与模型组比较,虾青素低剂量组(P<0.05)、中剂量组(P<0.05)、高剂量组(P<0.01)血脂、肝脂显著降低,组织病理切片显示肝细胞肿胀、坏死明显减轻,大部分肝细胞恢复正常。结论虾青素可明显改善高脂乳剂所致的肝细胞肿胀、坏死,虾青素对实验性大鼠脂肪肝模型具有一定的治疗作用。
OBJECTIVE To observe the therapeutic effect of astaxanthin on nonalcoholic fatty liver in rats.METHODS The model of nonalcoholic fatty liver was established by high fat emulsion method.The pathological changes of liver lipid,blood lipid,liver function and liver were observed.RESULTS Compared with normal control group,in model group,the levels of serum and liver lipids increased obviously(P<0.01),the pathological sections showed that the liver cells were swelling with necrosis,the structure of rat′s liver lobule was not clear.Compared with model group,astaxanthin low dose group(P<0.05),middle dose group(P<0.05),high dose group(P<0.01)had remarkably superior on decreasing serum and liver lipids,the pathological results indicated that liver cell swelling and necrosis were significantly reduced,most of liver cells recovered to the normal level.CONCLUSION Astaxanthin could significantly improve liver cell swelling and necrosis caused by high fat emulsion.Astaxanthin has certain therapeutic effect on fatty liver in rats.
作者
刘晓娟
万慧琪
许光辉
黄亦琦
罗友华
戚欢阳
LIU Xiao-juan;WAN Hui-qi;XU Guang-hui;HUANG Yi-qi;LUO You-hua;QI Huan-yang(Xiamen Medicine Research Institute,Xiamen 361008,China)
出处
《海峡药学》
2020年第11期18-21,共4页
Strait Pharmaceutical Journal
基金
厦门市科技惠民项目(NO.3502Z20174057)。
关键词
虾青素
非酒精性脂肪肝
大鼠
实验研究
Astaxanthin
Nonalcoholic Fatty Liver
Rats
Experimental study
