摘要
目的分析凝血功能在妊娠期与非妊娠期的差异性,探讨妊娠期的高凝状态与妊娠期高血压疾病凝血功能异常的区别,探索妊娠早、中、晚期凝血指标的参考区间,为临床预测凝血功能异常引起的疾病提供一定的诊疗依据。方法回顾性分析2017年5月至2019年8月在江苏省中西医结合医院产科门诊正常产检的妊娠妇女235例,将妊娠妇女按照怀孕时间分为三组,其中孕早期80例,孕中期85例,孕晚期70例,另选妊娠期高血压病例20例。选择未妊娠的生育期妇女50例。记录所有病例的年龄、体质量指数(BMI),回顾性分析所有病例的凝血功能,比较她们之间的相关性。结果妊娠期妇女凝血功能凝血酶原时间(PT)(12.51±0.51)s、活化部分的凝血活酶时间(APTT)(33.89±2.53)s、凝血酶时间(TT)(15.67±0.56)s、纤维蛋白原(FIB)(3.84±0.68)g/L、D二聚体(D-D)(0.85±0.56)ug/mL,未妊娠妇女PT为(13.35±0.29)s、APTT为(36.08±4.43)s、TT为(16.37±0.71)s、FIB(3.13±0.77)g/L、D-D为(0.19±0.52)ug/mL,妊娠妇女与未妊娠妇女相比PT、APTT、TT明显缩短,FIB、D-D明显升高,差异有统计学意义(P<0.05)。妊娠期高血压孕妇PT(11.36±0.56)s、APTT为(28.67±2.43)s、TT为(14.85±0.57)s、FIB(4.81±0.84)g/L、D-D为(1.53±0.87)ug/mL,妊高症组与妊娠妇女相比PT、APTT、TT明显缩短,FIB、D-D明显升高,与妊娠组相比差异有统计学意义(P<0.05)。妊高症组与未妊娠妇女相比PT、APTT、TT明显缩短,FIB、D-D明显升高,差异有统计学意义(P<0.05)。结论妊娠期凝血功能处于高凝状态,了解孕妇的凝血功能对孕妇凝血功能方面的疾病有重大的临床意义。
Objective To analyze the difference of coagulation function between pregnancy and non pregnancy,explore the difference between hypercoagulable state of pregnancy and abnormal coagulation function of hypertensive disorder complicating pregnancy,and explore the reference range of coagulation index in early,middle and late pregnancy,so as to provide certain diagnosis and treatment basis for clinical prediction of diseases caused by abnormal coagulation function.Methods A total of 235 pregnant women with normal obstetric examination in the obstetric outpatient department of Jiangsu Integrated Chinese and Western Medicine Hospital from May 2017 to August 2019 were selected.According to the time of pregnancy,pregnant women were divided into three groups,including 80 cases in early pregnancy,85 cases in mid pregnancy,70 cases in late pregnancy,and 20 cases of pregnancy induced hypertension.Fifty pregnant women in childbearing period were selected.The age and body mass index(BMI)of all patients were recorded.The coagulation function of all patients was analyzed retrospectively,and the correlation between them was compared.Results Prothrombin time(PT)(12.51±0.51)s,activated partial thromboplastin time(APTT)(33.89±2.53)s,thrombin time(TT)(15.67±0.56)s,fibrinogen(FIB)(3.84±0.68)g/L,D-Dimer(0.85±0.56)ug/mL in pregnant women,PT was(13.35±0.29)s,APTT was(36.08±4.43)s,TT was(16.37±0.71)s.FIB was(3.13±0.77)g/L and D-D was(0.19±0.52)ug/mL.PT,APTT and TT in pregnant women were significantly shorter than those in non pregnant women,and FIB and D-D were significantly increased.PT(11.36±0.56)s,APTT(28.67±2.43)s,TT(14.85±0.57)s,FIB(4.81±0.84)g/L,D-D was(1.53±0.87)ug/mL,PT,APTT,TT in PIH group were significantly shorter than those in pregnant women,FIB and D-D were significantly higher than those in pregnancy group.Compared with non pregnant women,PT,APTT,TT in PIH group were significantly shorter,FIB and D-D were significantly higher,the difference was statistically significant.Conclusion The clotting function in pregnancy is in a high coagulation state,to understand the clotting function of pregnant women in pregnant women's clotting function of the disease has great clinical significance.
作者
麻全慧
MA Quanhui(Jiangsu Integrated Chinese and Western Medicine Hospital,Nanjing,Jiangsu 210028,China)
出处
《大医生》
2020年第16期92-94,共3页
Doctor
关键词
妊娠期
凝血功能
高血压
pregnancy
coagulation function
hypertension
