摘要
目的评价成人糖尿病患者接种乙型肝炎疫苗(HepB)的免疫应答效果。方法通过7种中英文文献数据库,检索1989年1月-2019年12月发表的≥18岁糖尿病患者接种HepB后免疫应答的研究文献,进行Meta分析。结果共纳入8篇研究文献。Meta分析显示,糖尿病患者按照0-1-6月程序接种HepB后乙肝表面抗体(HBsAb)阳转率低于非糖尿病人群(合并OR=0.41,95%CI:0.33-0.50)。结论糖尿病可能是影响HepB免疫应答效果的危险因素。需探索糖尿病患者接种HepB的最佳免疫方案。
Objective To assess the immune response to hepatitis B vaccine(HepB)among adult diabetes patients.Methods We used 7 Chinese and English literature databases to search for studies on immune response to HepB vaccination among diabetes patients aged≥18 years published from January 1989 to December 2019;we conducted a meta-analysis.Results Eight studies were included.Meta-analysis showed that the seroconversion rate of hepatitis B surface antibody(HBsAb)after HepB vaccination using a 0-1-6-month immunization schedule was lower in diabetes patients than in patients without diabetes(combined OR=0.41,95%CI:0.33-0.50).Conclusions Diabetes is a risk factor for low immune response to HepB vaccine.We should explore an optimal HepB immunization schedule for patients with diabetes.
作者
韩冰峰
杜娟
王帅
赵天朔
刘贝
刘武
杨树博
刘雅琼
崔富强
Han Bingfeng;Du Juan;Wang Shuai;Zhao Tianshuo;Liu Bei;Liu Wu;Yang Shubo;Liu Yaqiong;Cui Fuqiang(School of Public Health,Peking University,Beijing 100191,China;Department of Infectious Diseases and Clinical Microbiology,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China;Jingyuan County Center for Disease Control and Prevention,Baiyin 730600,Gansu,China)
出处
《中国疫苗和免疫》
北大核心
2020年第5期578-582,共5页
Chinese Journal of Vaccines and Immunization
基金
北京大学医学部专项(BMU20170607)
“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项(2018ZX10721202)。
