摘要
由急性呼吸综合征相关冠状病毒2型(SARS-CoV-2)导致的新型冠状病毒病(COVID-19)目前在全球大流行。SARS-CoV-2这个RNA病毒是自然进化的产物,在中间宿主溢出人类并持续进化。目前SARS-CoV-2进化的趋势是传播能力增强。针对病毒传播途径阻断的疾病预防仍然是控制COVID-19流行的主要手段。对无症状感染者这个重要传染源的筛查和隔离是疾病预防的重点。疫苗免疫以保护易感人群的效果需要大规模人群进行评估。
Coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus type 2(SARS-CoV-2)is in the pandemic.SARS-CoV-2 is believed to originate from natural evolution.This RNA virus keeps evolving,even during spillover into humans via intermediate hosts.The evolutionary trend of SARS-CoV-2 in humans is characterized as an increased human-to-human transmission.The current major countermeasures against COVID-19 pandemic remain to be public health interventions,specifically targeting to the transmission pathway.In addition,the key point for the prophylaxis is to screen and isolate asymptomatic SARS-CoV-2 carriers,which may be a crucial source of infection.The efficiency of active immunization using vaccine to protect susceptible population needs to be extensively evaluated in population of large scale.
作者
曹广文
CAO Guang-wen(Department of Epidemiology,The Second Military Medical University,Shanghai 200433,China)
出处
《上海预防医学》
CAS
2020年第9期697-703,共7页
Shanghai Journal of Preventive Medicine
基金
国家自然科学基金(82041022)
上海市科学技术委员会资助项目(20JC1410200,20431900404)。
