摘要
目的探讨胃复春联合三联疗法治疗小儿幽门螺杆菌(Hp)感染相关胃炎的临床效果及对胃蛋白酶原(PG)表达的影响。方法选取我院2017年2月至2020年2月收治的150例Hp感染相关胃炎患儿,根据随机数字表法将其分为联合组(75例,胃复春+基于奥美拉唑的三联疗法)与对照组(75例,基于奥美拉唑的三联疗法)。治疗21 d后比较两组的治疗效果。结果联合组的治疗总有效率、Hp根除率均高于对照组(P<0.05)。两组治疗期间的主要不良反应为皮疹、胃肠道反应、恶心呕吐、头晕,组间比较,差异无统计学意义(P>0.05)。治疗后,两组的血清PGⅠ与PGⅡ水平均降低,且联合组明显低于对照组(P<0.05)。结论胃复春联合三联疗法治疗小儿Hp感染相关胃炎的临床效果显著,可提高Hp根除率,促进PG的正常表达,且不会增加不良反应。
Objective To investigate the clinical effect of Weifuchun combined with triple therapy in the treatment of Helicobactor pylori(Hp)infection related gastritis in children and its influence onpepsinogen(PG)expression.Methods A total of 150 children with Hp infection related gastritis admitted in our hospital from February 2017 to February 2020 were selected and divided into combination group(75 cases,Weifuchun+triple therapy based on omeprazole)and control group(75 cases,triple therapy based on omeprazole)by random number table method.After 21 d of treatment,the therapeutic effects of the two groups were compared.Results The total effective rate of treatment and Hp eradication rate of the combination group were higher than those of the control group(P<0.05).The main adverse reactions in the two groups during treatment were rash,gastrointestinal reactions,nausea and vomiting,dizziness,and there were no statistically significant differences between the two groups(P>0.05).After treatment,the serum PGⅠand PGⅡlevels of the two groups decreased,and those in the combination group were significantly lower than the control group(P<0.05).Conclusion Weifuchun combined with triple therapy in the treatment of Hp infection related gastritis in children has a significant clinical effect,which can increase the eradication rate of Hp,promote the normal expression of PG,and will not increase the adverse reactions.
作者
白庆峰
刘菲
拜博
赵婷
张彬钰
BAI Qingfeng;LIU Fei;BAI Bo;ZHAO Ting;ZHANG Binyu(Pediatrics Department,Shangluo Central Hospital,Shangluo 726000;Neonatology Department,Ankang Maternal and Child Health Care Hospital,Ankang 725000,China)
出处
《临床医学研究与实践》
2020年第35期116-118,共3页
Clinical Research and Practice
