摘要
目的探讨女性急性心肌梗死(acute myocardial infarction,AMI)患者的血清尿酸水平与心功能分级的关系。方法入选2016年12月1日至2019年1月31日在河南省人民医院急诊住院治疗的178例女性AMI患者。由病历收集患者的基本信息、血清尿酸、心电图及血液生化检查资料。依据心功能Killip分级分为Killip低分级组和Killip高分级组。应用t检验或Mann-Whitney U检验比较不同Killip分级组患者血清尿酸水平的差异。结果 (1)与Killip低分级组相比,Killip高分级组患者年龄(69岁vs 65岁,P<0.05)和糖尿病患者比例均显著较高(55%vs 25%,P<0.05),总胆固醇和低密度脂蛋白水平则明显偏低(P<0.05)。(2)Killip高分级组患者的血清尿酸水平显著高于Killip低分级组患者(5.24 mg/dl vs 4.15 mg/dl,P<0.05)。(3)按疾病史分层分析显示,在非糖尿病(5.45 mg/dl vs 4.15 mg/dl)或非血脂异常(5.33 mg/dl vs 4.22 mg/dl)患者中,Killip高分级组患者的血清尿酸水平显著性高于低分级组(P<0.05)。结论女性AMI患者的血尿酸水平与Killip分级相关,尿酸水平越高,患者Killip分级越高。血清尿酸水平可能是女性AMI患者心功能Killip分级的良好预测指标,尤其对于无糖尿病和无血脂异常的患者。
Objective To explore the relationship between the level of serum uric acid(UA) and Killip class among female patients with acute myocardial infarction(AMI).Methods The total of 178 female patients diagnosed with AMI were enrolled from December 1, 2016 to January 31, 2019 in Henan Provincial People’s Hospital. The information on demographics the level of UA, laboratory examination and echocardiography were collected from the medical records. The patients were divided into Killip low-grade and Killip high-grade groups based on the Killip class. Student’s t-test and Mann-Whitney U Test were used to evaluate the association of the level of UA and Killip class.Results(1)Compared to the Killip low-grade group, the age(69 yrs vs 65 yrs) and the proportion of diabetic patients(55% vs 25%) were significantly higher(P<0.05), while the levels of total cholesterol and low-density lipoprotein were significantly lower in the high-grade group(P<0.05).(2)The level of serum UA in high-grade group was significantly higher than that in low-grade group(5.24 mg/dl vs 4.15 mg/dl, P<0.05).(3)Stratified analysis showed that the serum UA level of high-grade group was significantly higher than that of low-grade group in patients without diabetes(5.45 mg/dl vs 4.15 mg/dl, P<0.05) or dyslipidemia(5.33 mg/dl vs 4.22 mg/dl, P<0.05).Conclusion Level of serum UA in female AMI patients was associated with Killip grade. The higher level of serum UA was, the higher Killip grade was. The serum UA might be a good predictor of Killip classification of cardiac function in female patients with AMI, especially in patients without diabetes or dyslipidemia.
作者
刘晓宇
赵婧宇
卢冰月
任琢琢
高东洋
王留义
LIU Xiao-yu;ZHAO Jing-yu;LU Bing-yue;REN Zhuo-zhuo;GAO Dong-yang;WANG Liu-yi(Department of General Medicine,Henan Provincial People’s Hospital,Zhengzhou 450003,China)
出处
《医药论坛杂志》
2020年第11期1-4,8,共5页
Journal of Medical Forum
基金
河南省科技攻关项目(162102310291)。
