摘要
目的:将黄芩苷与聚氧化乙烯(PEO)、聚乙二醇6000(PEG6000)制成缓释固体分散体,控制黄芩苷缓慢稳定释放。方法:采用溶剂蒸发法,将不同比例的黄芩苷、PEO、PEG6000溶于95%乙醇中,以制备黄芩苷-PEO-PEG6000固体分散体,对比黄芩苷原料药及其制剂的体外溶出结果,通过物相表征手段对所形成的固体分散体进行鉴别。结果:黄芩苷与PEO、PEG6000按1∶1∶3制备的固体分散体,药物缓慢释放,8 h时体外累积释放的药物有90%左右;黄芩苷以无定型的形式分散在该缓释固体分散体中。结论:以PEO-PEG6000为载体制备的黄芩苷缓释固体分散体,药物释放较完全且可控缓慢释放,制剂工艺简单,具有潜在应用价值。
Objective:To prepare baicalin sustained release solid dispersion,using polyethylene oxide(PEO)and polyethylene glycol 6000(PEG6000)as carriers,with the intention of controlling baicalin stable release slowly and reducing its side effect.Methods:The different proportions of baicalin,PEO,PEG6000 were dissolved in 95%ethanol.The baicalin sustained release solid dispersion was prepared by solvent evaporation method.The in vitro dissolution was also investigated.The formation of solid dispersion were discriminate by scanning electron microscopy,differential scanning and X-ray diffraction.Results:The ideal solid dispersion was prepared with the weight ratio of baicalin and PEO,PEG60001:3:1.The baicalin release slowly with accumulated release about 90%in 8 h.The results demonstrated that baicalin existed in non-crystalline form.Conclusion:The sustained release solid dispersion of baicalin prepared with PEG6000 as the carrier,could control the release rate of drug and keep moderate and controllable,and the preparation process is simple,which has potential applications.
作者
严红梅
祁秀秀
Yan Hongmei;Qi Xiuxiu(Changzhou Vocational Institute of Engineering,Changzhou 213164,China)
出处
《广东化工》
CAS
2020年第22期245-248,共4页
Guangdong Chemical Industry
基金
常州工程职业技术学院2018年校科研基金(项目编号:11130300118011)。
