摘要
目的探讨血清胎球蛋白B(Fetuin B)水平与2型糖尿病周围神经病变(DPN)的关系。方法选取2018年7月至2019年3月中山大学附属中山医院内分泌专科治疗的82例2型糖尿病(T2DM)患者分为T2DM组(46例)和DPN组(36例)。选取同时期45例体检健康者作为对照组。分析DPN患者血清Fetuin B、肝肾功能、血压、血脂、尿酸和同型半胱氨酸(Hcy)水平变化情况。结果DPN组的Fetuin B水平高于T2DM组和对照组,T2DM组的Fetuin B水平高于对照组,差异均有统计学意义(P<0.05)。DPN组和T2DM组的Hcy水平高于对照组,差异有统计学意义(P<0.05)。二元Logistic回归分析结果显示,Fetuin B、总胆固醇、高密度脂蛋白和Hcy是DPN的独立危险因素。受试者工作特征(ROC)曲线结果显示,血清Fetuin B在19.639 ng/mL时,具有较好的诊断价值(AUC:0.967,灵敏度:0.933,特异度:0.977)。结论血清中Fetuin B升高可能会使T2DM患者增加DPN的患病风险,监测血清中Fetuin B水平变化情况,有助于早期发现DPN患者。
Objective To investigate the relationship between serum Fetuin B level and diabetic peripheral neuropathy(DPN).Methods From July 2018 to March 2019,a total of 72 type 2 diabetic(T2MD)patients receiving endocrine therapy in Zhongshan Hospital of Sun Yat-Sun University were divided into T2DM group(46 cases)and DPN group(36 cases).Another 45 healthy persons were selected as the control group.Changes of serum Fetuin B,liver and kidney function,blood pressure,blood lipid,uric acid and homocystine(Hcy)levels in DPN patients were analyzed.Results The level of Fetuin B in DPN group was higher than that in T2DM group and control group,the level of Fetuin B in T2DM group was higher than that in control group,and the differences were statistically significant(P<0.05).Hcy levels in DPN group and T2DM group were higher than that in control group,and the differences were statistically significant(P<0.05).Binary logistic regression analysis results showed that Fetuin B,total cholesterol,high density lipoprotein and Hcy were independent risk factors for DPN.Receiver operating characteristic(ROC)curve results showed that serum Fetuin B at 19.639 ng/mL had good diagnostic value(AUC:0.967,sensitivity:0.933,specificity:0.977).Conclusion Elevated serum Fetuin B may increase the risk of DPN in patients with T2DM.Monitoring the changes in serum Fetuin B level is helpful for early detection of DPN patients.
作者
陈树鑫
宁晔
黄永洪
韩登科
CHEN Shuxin;NING Ye;HUANG Yonghong;HAN Dengke(Emergency Center,Zhongshan Hospital of Sun Yat-Sun University,Zhongshan,Guangdong 528403,China;Department of Internal Medicine,Zhongshan Port Hospital,Zhongshan,Guangdong 528447,China;Laboratory Medicine Center,Zhongshan Hospital of Sun Yat-Sun University,Zhongshan,Guangdong 528403,China)
出处
《国际检验医学杂志》
CAS
2020年第24期2974-2977,共4页
International Journal of Laboratory Medicine
基金
广东省中山市医学科研基金项目(2019J040)。
