摘要
富血小板血浆(PRP)是自体或异体全血离心后制备的血小板浓缩物,含有大量生长因子和蛋白质,具有促进组织再生修复、血管生成等生物学功能,被广泛应用于骨科、眼科、口腔科、皮肤科等,且效果显著,无严重不良反应。越来越多研究将PRP应用于生育力保护,PRP可改善子宫内膜容受性、卵巢储备功能、化疗后及缺血损伤后生殖器官结构和功能的恢复、男女生殖内分泌和性行为。但PRP未实现标准化制备,离心转速、离心时间、抗凝剂、激活剂、保存时间、冷冻温度、保存剂、志愿者特征等因素均可能影响其质量。该文综述PRP在生育力保护方面的研究进展、PRP质量的影响因素及PRP应用中存在的安全性问题,以期为PRP的临床应用提供参考依据。
Platelet rich plasma(PRP)is a platelet concentrate prepared by centrifugation of autologous or allogeneic whole blood.It contains a large number of growth factors and proteins.It has biological functions such as promoting tissue regeneration and repair,angiogenesis and so on.It has been widely used in orthopedics,ophthalmology,stomatology,dermatology and so on,with significant effect and no serious adverse reactions.At present,more and more studies have applied PRP to fertility protection.Lots of articles reported that PRP can improve endometrial receptivity,ovarian reserve function,recovery of reproductive organ structure and function after chemotherapy and ischemic injury,reproductive endocrine and sexual behavior of both men and women.But the preparation standards are not uniform.Centrifugal speed,centrifugal time,anticoagulant,activator,storage time,freezing temperature,preservative,volunteer characteristics and other factors may all affect its quality.This study discusses the research progress of PRP in fertility protection,the influencing factors of PRP quality and the safety issues in the hope of providing a reference basis for its clinical application.
作者
李晓凤
王芳
杨凤娜
陶丽梅
杨欣(审校)
LI Xiao-feng;WANG Fang;YANG Feng-na;TAO Li-mei;YANG Xin(Lanzhou University Second Hospital,Lanzhou 730000,China)
出处
《国际妇产科学杂志》
CAS
2020年第6期699-704,共6页
Journal of International Obstetrics and Gynecology
基金
国家自然科学基金(81960515)。
